Guanfacine and clonidine, alpha2-agonists, improve paired associates learning, but not delayed matching to sample, in humans
Guanfacine and clonidine, alpha2-agonists, improve paired associates learning, but not delayed matching to sample, in humans
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DOI：
10.1016/s0893-133x(98)00055-4
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发表时间：
1999-02-01
影响因子：
7.6
通讯作者：
Riekkinen, P
中科院分区：
文献类型：
--
作者：
Jäkälä, P;Sirviö, J;Riekkinen, P
本研究比较了两种α 2受体激动剂可乐定（0.5，2和5 μ g/kg，PO）和胍法辛（7和29 μ g/kg，PO）对年轻健康志愿者在视觉配对联想学习（PAL）和延迟匹配样本（DMTS）视觉短时识别记忆测试中的表现的影响。在PAL测试中，可乐定2和胍法辛29 μ g/kg改善了受试者的表现。在DMTS测试中，可乐定在5微克/公斤延迟依赖性损害性能的准确性，并在2和5微克/公斤，它也减缓了反应。胍法辛对DMTS测试性能没有影响。可乐定5和胍法辛29 μ g/kg同样增加了镇静和降低血压的主观感觉。结果表明，可乐定和胍法辛促进PAL学习，通过改善“额叶策略”，但只有可乐定破坏“记忆加工”降低DMTS的准确性。胍法辛对α 2A-肾上腺素受体亚型的更高选择性可能解释了药物作用的不同特征。[Neuropsychopharmacology 20：119-130，1999]（C）1998年美国神经精神药理学学院。出版社：Elsevier Science Inc.
The present study compares the effects of two alpha2-agonists, clonidine (0.5, 2, and 5 mu g/kg, PO) and guanfacine (7 and 29 mu g/kg, PO) in young healthy volunteers on their performance in visual paired associates learning (PAL) and delayed matching to sample (DMTS) visual short-term recognition memory tests. In the PAL test, clonidine 2 and guanfacine 29 mu g/kg improved the subjects' performance. In the DMTS test, clonidine at 5 mu g/kg delay-dependently impaired performance accuracy, and at 2 and 5 mu g/kg it also slowed responses. Guanfacine had no effect on DMTS test performance. Clonidine 5 and guanfacine 29 mu g/kg equally increased subjective feelings of sedation and reduced blood pressure. The results suggest that both clonidine and guanfacine facilitated PAL learning by improving "frontal strategies," but only clonidine disrupted "mnemonic processing" decreasing DMTS accuracy. The greater selectivity of guanfacine for alpha2A-adrenoceptor subtype may explain the different profile of action of the drugs. [Neuropsychopharmacology 20: 119-130, 1999] (C) 1998 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.