Influence of acid-base status on plasma catecholamines during exercise in normal humans.
Influence of acid-base status on plasma catecholamines during exercise in normal humans.
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正常人运动时酸碱状态对血浆儿茶酚胺的影响。
DOI：
10.1152/ajpregu.1990.258.6.r1411
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Davies,SF
中科院分区：
文献类型：
--
作者：
Goldsmith,SR;Iber,C;McArthur,CD;Davies,SF
本文研究了6名健康志愿者运动时酸碱状态对血浆中儿茶酚胺的影响。在四种条件下，在自行车测力计上进行递增运动至175 W：1）对照，2）在强迫过度通气（HV）期间，3）用乙酰唑胺（阿泽）预处理后，和4）同时呼吸4%CO2。尽管HV期间静息pH较高，而阿泽后静息pH较低，但四种方案之间静息血浆去甲肾上腺素（PNE）和肾上腺素（PE）无差异[对照组，7.4 +/- 0.02; HV，7.48 +/- 0.03（P小于0.005）;阿泽，7.36 +/- 0.01（P小于0.005）（P值表示与对照方案存在显著差异）]。在4% CO2研究期间，静息pH值与对照组无差异（7.4 +/- 0.01）。在175 W运动负荷下，pH和PNE均存在显著差异。在对照试验期间，pH为7.38 +/- 0.02，PNE为951 +/- 164 pg/ml，PE为264 +/- 132 pg/ml。HV期间，pH值为7.46 +/- 0.5（P <0.001），PNE为976 +/- 67 pg/ml，PE为210 +/- 27 pg/ml。阿泽后，pH为7.31 +/- 0.2（P <0.001），PNE为1，866 +/- 561 pg/ml（P <0.005），PE为382 +/- 264 pg/ml。当受试者呼吸4%CO2时，pH为7.29 ± 0.02（P <0.001），PNE为1.842 ± 617 pg/ml（P <0.01），PE为467 ± 275 pg/ml。（250字处删节）
The influence of acid-base status on plasma catecholamines during exercise was investigated in six healthy volunteers. Incremental exercise to 175 W was performed on a bicycle ergometer under four conditions: 1) control, 2) during forced hyperventilation (HV), 3) after pretreatment with acetazolamide (AZE), and 4) while breathing 4% CO2. Resting plasma norepinephrine (PNE) and epinephrine (PE) were not different among the four protocols despite higher resting pH during HV and lower resting pH after AZE [control, 7.4 +/- 0.02; HV, 7.48 +/- 0.03 (P less than 0.005); AZE, 7.36 +/- 0.01 (P less than 0.005) (P values indicate significant differences from the control protocol)]. Resting pH was not different from control during the 4% CO2 study (7.4 +/- 0.01). At the 175-W exercise load, there were significant differences in both pH and PNE. During the control test, pH was 7.38 +/- 0.02, PNE was 951 +/- 164 pg/ml, and PE was 264 +/- 132 pg/ml. During HV, pH was 7.46 +/- 0.5 (P less than 0.001), PNE was 976 +/- 67 pg/ml, and PE was 210 +/- 27 pg/ml. After AZE, pH was 7.31 +/- 0.2 (P less than 0.001), PNE was 1,866 +/- 561 pg/ml (P less than 0.005), and PE was 382 +/- 264 pg/ml. While subjects breathed 4% CO2, pH was 7.29 +/- 0.02 (P less than 0.001), PNE was 1.842 +/- 617 pg/ml (P less than 0.01), and PE was 467 +/- 275 pg/ml.(ABSTRACT TRUNCATED AT 250 WORDS)