Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: the Hisayama Study.
Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: the Hisayama Study.
复制标题
DOI：
10.1253/circj.cj-12-1548
复制
发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
T. Usui;T. Ninomiya;M. Nagata;Otowa Takahashi;Y. Doi;J. Hata;M. Fukuhara;T. Kitazono;Y. Oike;Y. Kiyohara
中科院分区：
文献类型：
--
作者：
T. Usui;T. Ninomiya;M. Nagata;Otowa Takahashi;Y. Doi;J. Hata;M. Fukuhara;T. Kitazono;Y. Oike;Y. Kiyohara
血管生成素样蛋白2 （Angptl2）是一种促进炎症和血管内皮功能障碍的脂肪因子。本研究的目的是探讨血清Angptl2水平与慢性肾脏疾病（CKD）的关系。方法与结果将3169名年龄≥40岁的社区居民按Angptl2水平分为五分位数。CKD定义为存在蛋白尿（尿白蛋白-肌酐比值≥30.0mg/g）或肾小球滤过率降低（eGFR <60ml·min（-1）·1.73m(-2)）。使用逻辑回归模型计算CKD存在的优势比（OR）。CKD的总患病率为37.5%。随着血清Angptl2水平的升高，CKD存在的年龄和性别调整的ORs增加。在调整了已知的心血管危险因素后，这一趋势仍然显著(<2.01ng/ml: OR, 1.00（参考）；2.01-2.48ng/ml: OR, 1.67, 95%可信区间[CI]: 1.24-2.24；2.49-2.99ng/ml: OR, 1.70, 95% CI: 1.27-2.28；3.00-3.65ng/ml: OR, 1.78, 95% CI: 1.32-2.39；≥3.66ng/ml: OR, 1.79, 95% CI: 1.32-2.43；趋势的p值=0.001)。血清Angptl2升高显著增加了蛋白尿存在的多变量调整ORs（趋势p值=0.004），而血清Angptl2水平与eGFR降低之间无显著关系（趋势p值=0.08）。结论：在普通人群中，血清Angptl2升高与CKD发生的可能性相关。
BACKGROUND Angiopoietin-like protein 2 (Angptl2) is an adipokine that promotes inflammation and endothelial dysfunction of the vessels. The aim of this study was to investigate the relationship between serum Angptl2 level and chronic kidney disease (CKD). METHODS AND RESULTS A total of 3,169 community-dwelling subjects aged ≥40 years were divided into quintiles by Angptl2 level. CKD was defined as the presence of albuminuria (urine albumin-creatinine ratio ≥30.0mg/g) or decreased estimated glomerular filtration rate (eGFR <60ml·min(-1)·1.73m(-2)). The odds ratio (OR) for the presence of CKD was calculated using a logistic regression model. The overall prevalence of CKD was 37.5%. The age- and sex-adjusted ORs for the presence of CKD increased with higher serum Angptl2 level. This trend remained significant after adjusting for known cardiovascular risk factors (<2.01ng/ml: OR, 1.00 (reference); 2.01-2.48ng/ml: OR, 1.67, 95% confidence interval [CI]: 1.24-2.24; 2.49-2.99ng/ml: OR, 1.70, 95% CI: 1.27-2.28; 3.00-3.65ng/ml: OR, 1.78, 95% CI: 1.32-2.39; ≥3.66ng/ml: OR, 1.79, 95% CI: 1.32-2.43; P-value for trend=0.001). Multivariate-adjusted ORs for the presence of albuminuria increased significantly with elevated serum Angptl2 (P-value for trend=0.004), while there was no evidence of a significant relationship between serum Angptl2 level and decreased eGFR (P-value for trend=0.08). CONCLUSIONS Elevated serum Angptl2 is associated with the likelihood of CKD in the general population.