Oxytocin and cancer: An emerging link.
Oxytocin and cancer: An emerging link.
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催产素与癌症： 新出现的联系
DOI：
10.5306/wjco.v9.i5.74
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发表时间：
2018-09-14
影响因子：
2.8
通讯作者：
Ogunwobi OO
中科院分区：
文献类型：
--
作者：
Lerman B;Harricharran T;Ogunwobi OO
脑垂体后叶分泌的神经肽激素催产素参与许多生理过程。由于这一领域的新研究，对其影响的了解正在逐渐增加。虽然大多数人认为催产素是一种生殖系统激素，但它也调节其他器官系统，如大脑和心血管系统。最近，研究的重点是解开它在癌症中的作用，新出现的证据表明催产素作为癌症生物标志物的潜在作用。这篇综述总结了催产素和癌症之间的联系，特别强调了前列腺癌，它可能会促进细胞增殖。研究表明，催产素的作用可能取决于细胞类型，激素的浓度，它与微环境中其他激素的相互作用，以及其受体在细胞膜上的精确定位。未来的研究需要进一步阐明催产素在癌症中的作用，以及它是否可以成为临床癌症生物标志物或治疗靶点。
The neuropeptide hormone oxytocin, which is released from the posterior pituitary gland, is involved in a number of physiological processes. Understanding of its effects is gradually increasing due to new research in this area. While mostly recognized as a reproductive system hormone, oxytocin also regulates other organ systems such as the brain and cardiovascular system. Recently, research has focused on unraveling its involvement in cancer, and emerging evidence suggests a potential role for oxytocin as a cancer biomarker. This review summarizes observations linking oxytocin and cancer, with a special emphasis on prostate cancer, where it may promote cell proliferation. Research suggests that oxytocin effects may depend on cell type, concentration of the hormone, its interactions with other hormones in the microenvironment, and the precise localization of its receptor on the cell membrane. Future research is needed to further elucidate the involvement of oxytocin in cancer, and whether it could be a clinical cancer biomarker or therapeutic target.