Role of spinal cord glutamate transporter during normal sensory transmission and pathological pain states.
Role of spinal cord glutamate transporter during normal sensory transmission and pathological pain states.
复制标题
脊髓谷氨酸转运蛋白在正常感觉传播和病理疼痛状态中的作用。
DOI：
10.1186/1744-8069-1-30
复制
发表时间：
2005-10-21
期刊：
影响因子：
3.3
通讯作者：
Stephens, Robert L Jr
中科院分区：
文献类型：
--
作者：
Tao, Yuan-Xiang;Gu, Jianguo;Stephens, Robert L Jr
谷氨酸是一种神经递质，对脊髓兴奋性突触传递以及通过激活谷氨酸受体产生和维持脊髓疼痛超敏状态至关重要。了解突触和非突触释放的谷氨酸对病理性疼痛的调控对探索病理性疼痛的分子机制和发展治疗策略具有重要意义。谷氨酸转运体系统是失活突触释放的谷氨酸和维持谷氨酸稳态的主要机制。近年来的研究表明，抑制脊髓谷氨酸转运体可以减轻病理性疼痛，提示脊髓谷氨酸转运体可能成为治疗病理性疼痛的靶点。然而，谷氨酸转运体在病理性疼痛中的确切功能还不完全清楚。本报告将审查脊髓谷氨酸转运蛋白在正常感觉传递和病理性疼痛条件下的作用的证据，并讨论脊髓谷氨酸转运蛋白参与病理性疼痛的潜在机制。
Glutamate is a neurotransmitter critical for spinal excitatory synaptic transmission and for generation and maintenance of spinal states of pain hypersensitivity via activation of glutamate receptors. Understanding the regulation of synaptically and non-synaptically released glutamate associated with pathological pain is important in exploring novel molecular mechanisms and developing therapeutic strategies of pathological pain. The glutamate transporter system is the primary mechanism for the inactivation of synaptically released glutamate and the maintenance of glutamate homeostasis. Recent studies demonstrated that spinal glutamate transporter inhibition relieved pathological pain, suggesting that the spinal glutamate transporter might serve as a therapeutic target for treatment of pathological pain. However, the exact function of glutamate transporter in pathological pain is not completely understood. This report will review the evidence for the role of the spinal glutamate transporter during normal sensory transmission and pathological pain conditions and discuss potential mechanisms by which spinal glutamate transporter is involved in pathological pain.