COCARCINOGENIC AND TUMOR-PROMOTING AGENTS IN TOBACCO CARCINOGENESIS
COCARCINOGENIC AND TUMOR-PROMOTING AGENTS IN TOBACCO CARCINOGENESIS
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DOI：
10.1093/jnci/56.6.1237
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发表时间：
1976-01-01
影响因子：
10.3
通讯作者：
GOLDSCHMIDT, BM
中科院分区：
文献类型：
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作者：
VANDUUREN, BL;GOLDSCHMIDT, BM
对一系列21种烟草烟雾成分和相关化合物在小鼠皮肤上进行了致癌活性测试。将化合物与低剂量（5 μg/应用）苯并[a]芘（B[a]P）一起应用于小鼠皮肤（50只雌性ICR/Ha Swiss小鼠/组），每周三次。测试化合物分为五类：脂肪烃、芳香烃、酚类、长链酸和醇类。邻苯二酚、邻苯三酚、癸烷、十一烷、芘、苯并[e]芘和荧蒽等化合物对B[a]P的致癌性有明显的增强作用。以下化合物完全抑制B[a]P致癌性：七叶苷、槲皮素、角鲨烯和油酸。苯酚、丁香酚、间苯二酚、对苯二酚、十六烷和柠檬烯部分抑制B[a]P致癌性。21种化合物中的6种也在两阶段致癌作用中作为肿瘤促进剂进行了测试。无直接相关性存在肿瘤-premotetrin活性和cocarcinogenic活性。助致癌物邻苯三酚和邻苯二酚没有显示出促肿瘤活性。癸烷、十四烷、蒽林和佛波醇肉豆蔻酸酯乙酸酯显示两种类型的活性。描述了结构-活性关系和可能的作用模式。
A series of 21 tobacco smoke components and related compounds were tested for cocarcinogenic activity on mouse skin. The compounds were applied to mouse skin (50 female ICR/Ha Swiss mice/group) three times weekly with a low dose (5 µg/application) of benzo[a]pyrene (B[a]P). The test compounds were of five classes: aliphatic hydrocarbons, aromatic hydrocarbons, phenols, and long-chain acids and alcohols. The following compounds enhanced remarkably the carcinogenicity of B[a]P: catechol, pyrogallol, decane, undecane, pyrene, benzo[e]pyrene, and f1uoranthene. The following compounds inhibited B[a]P carcinogenicity completely: esculin, quercetin, squalene, and oleic acid. Phenol, eugenol, resorcinol, hydroquinone, hexadecane, and limonene partially inhibited B[a]P carcinogenicity. Six of the 21 compounds were also tested as tumor promoters in two-stage carcinogenesis. No direct correlation existed between tumer-premotlng activity and cocarcinogenic activity. The cocarcinogens pyrogallol and catechol did not show tumor-promoting activity. Decane, tetradecane, anthralin, and phorbol myristate acetate showed both types of activity. Structure-activity relationships and possible modes of action were described.