Interagency registry for mechanically assisted circulatory support report on the total artificial heart
Interagency registry for mechanically assisted circulatory support report on the total artificial heart
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DOI：
10.1016/j.healun.2018.04.004
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发表时间：
2018-11-01
影响因子：
8.9
通讯作者：
Kirklin, James K.
中科院分区：
文献类型：
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作者：
Arabia, Francisco A.;Cantor, Ryan S.;Kirklin, James K.
背景技术背景：我们试图通过评估来自机械辅助循环支持跨机构登记处的数据，更好地了解接受临时全人工心脏（TAH）作为移植桥梁或决定桥梁的患者人群（INTERMACS）数据库。我们检查了与生存率，不良事件，2006年6月至2017年4月期间接受TAH的患者的结局和竞争性结局，并使用风险函数分析探索死亡率的风险因素。（87%男性;平均年龄50岁）可在INTERMACS数据库中获得。最常见的2种诊断是扩张型心肌病（50%）和缺血性心肌病（20%）。82%的患者存在右心衰竭的危险因素。大多数患者在植入时为INTERMACS Profile 1（43%）或2（37%）。有266名患者最终接受了移植，162人死亡。总体3、6和12个月精算生存率分别为73%、62%和53%。死亡的危险因素包括年龄较大（p = 0.001），需要植入前透析（p = 0.006），较高的肌酐（p = 0.008）和较低的白蛋白（p < 0.001）水平，以及在低容量中心植入（
BACKGROUND: We sought to better understand the patient population who receive a temporary total artificial heart (TAH) as bridge to transplant or as bridge to decision by evaluating data from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database.METHODS: We examined data related to survival, adverse events, and competing outcomes from patients who received TAHs between June 2006 and April 2017 and used hazard function analysis to explore risk factors for mortality.RESULTS: Data from 450 patients (87% men; mean age, 50 years) were available in the INTERMACS database. The 2 most common diagnoses were dilated cardiomyopathy (50%) and ischemic cardiomyopathy (20%). Risk factors for right heart failure were present in 82% of patients. Most patients were INTERMACS Profile 1 (43%) or 2 (37%) at implantation. There were 266 patients who eventually underwent transplantation, and 162 died. Overall 3-, 6-, and 12-month actuarial survival rates were 73%, 62%, and 53%, respectively. Risk factors for death included older age (p = 0.001), need for pre-implantation dialysis (p = 0.006), higher creatinine (p = 0.008) and lower albumin (p < 0.001) levels, and implantation at a low-volume center (