Scalp acupuncture effects of stroke studied with magnetic resonance imaging: different actions in the two stroke model rats
Scalp acupuncture effects of stroke studied with magnetic resonance imaging: different actions in the two stroke model rats
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DOI：
10.1136/aim.2009.000430
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发表时间：
2009-12-01
影响因子：
2.5
通讯作者：
Ishikawa, Makoto
中科院分区：
文献类型：
--
作者：
Inoue, Isao;Fukunaga, Mari;Ishikawa, Makoto
研究背景：头针治疗脑卒中在我国已有一定的临床经验并广泛应用。方法：采用MRI观察头针对自发性高血压卒中易感（SHR-SP）大鼠和大脑中动脉阻断2 h造成的短暂性局灶性脑缺血大鼠的影响结果：SHR-SP大鼠卒中发作的特点是血管源性水肿的发展，而没有任何细胞毒性水肿的外观。头针可迅速减轻SHR-SP大鼠神经功能障碍，并在同一时期减少血管源性水肿的体积。相比之下，在MCAO大鼠中，局灶性脑缺血导致细胞毒性水肿的立即发展，而没有任何血管源性水肿的外观。再灌注后出现血管源性水肿。头针没有显着影响的细胞毒性水肿，血管源性水肿或神经功能障碍的MCAO大鼠在检查的时间跨度inspected.Conclusion：头针有一个快速和强大的影响，只有在高血压脑卒中模型，通过减少血管源性水肿的神经功能障碍。我们的研究结果表明，如果有类似的潜在机制，在人类中风，头针可能是更有益的高血压引起的血管源性中风患者比缺血性起源。
Background: Scalp acupuncture (SA) therapy on strokes has been empirically established and widely used in clinics in China. The evidence from clinical studies suggests that SA produces significant benefits for some patients with stroke.Methods: The effect of scalp acupuncture was studied using MRI for two different stroke models: spontaneously hypertensive stroke-prone (SHR-SP) rats and rats with transiently induced focal cerebral ischaemia by middle cerebral artery occlusion for 2 h (MCAO rats).Results: Stroke onset in SHR-SP rats was characterised by a development of vasogenic oedema without any appearance of cytotoxic oedema. Scalp acupuncture reduced rapidly neurological dysfunction in SHR-SP rats and reduced the volume of the vasogenic oedema during the same period. In contrast, in MCAO rats, focal cerebral ischaemia caused an immediate development of cytotoxic oedema without any appearance of vasogenic oedema. Vasogenic oedema developed after reperfusion. Scalp acupuncture had no significant effects on the cytotoxic oedema, vasogenic oedema or neurological dysfunction of the MCAO rats within the time span examined.Conclusion: Scalp acupuncture had a rapid and strong effect on neurological dysfunction only in the hypertensive stroke-model by reducing the vasogenic oedema. Our results suggest that, if there are similar underlying mechanisms in human strokes, scalp acupuncture may be more beneficial for patients with strokes of hypertension-caused vasogenic origin than ischaemic origin.