Inositol phosphoglycans in diabetes and obesity: Urinary levels of IPG A-type and IPG P-type, and relationship to pathophysiological changes
Inositol phosphoglycans in diabetes and obesity: Urinary levels of IPG A-type and IPG P-type, and relationship to pathophysiological changes
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DOI：
10.1006/mgme.1999.2936
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发表时间：
1999-12-01
影响因子：
3.8
通讯作者：
Rademacher, TW
中科院分区：
文献类型：
--
作者：
Kunjara, S;Wang, DY;Rademacher, TW
在成年男性糖尿病患者和对照组中，测量了尿中肌醇磷酸聚糖（IPGs）， IPG a型和IPG p型形式的含量，它们在其他作用中调节葡萄糖利用、脂肪生成、甘油三酯形成和丙酮酸脱氢酶（PDH）活性的途径。与对照组相比，整个糖尿病组尿液中IPG a型升高2- 3倍，IPG p型和IPG a型比值下降，将糖尿病患者细分为瘦型IDDM组和肥胖型NIDDM组，IPG有显著差异；p型：各组间IPG a型比值，该比值随体重指数（BMI）的增加而降低。IPGs与HbA1、血压、BMI的关系分析。IPG p型：IPG a型比值的下降与HbA1升高（表明血糖控制受损）、收缩压升高和肥胖增加相关，所有这些因素都与x综合征相关。IPG p型：IPG a型比值的分布与胰岛素抵抗和BMI的既定模式存在相似之处。体外研究IPG p型：IPG a型比例的改变对PDH磷酸酶反应中丙酮酸脱氢酶复合体（PDH复合体）激活的影响表明，IPG a型形式拮抗IPG p型形式对PDH磷酸酶的刺激，从而对PDH向活性、去磷酸化形式的转化产生负面影响。这一观察结果可以提供一种机制，即上述IPG p型：IPG a型比率的变化可以改变代谢模式，从一种以葡萄糖氧化为导向的代谢模式转变为一种以能量节约和脂质储存为导向的代谢模式，(C) 1999学术出版社。
Measurements have been made, in adult male diabetic patients and control subjects, of the urinary content of inositol phosphoglycans (IPGs), the IPG A-type and IPG P-type forms, which, among other actions, regulate pathways of glucose utilization, lipogenesis, triglyceride formation, and pyruvate dehydrogenase (PDH) activity. Urine samples from the entire diabetic group showed a 2- to 3-fold increase in IPG A-type, and a fall in the IPG P-type: IPG A-type ratio relative to the control group, Subdivision of the diabetic patients into lean IDDM and obese NIDDM groups revealed significant differences in the IPG; P-type:IPG A-type ratio between these groups, this ratio decreasing with increases in the body mass index (BMI). Analysis of the relationships among IPGs and HbA1, blood pressure, and BMI. indicated that a fall in the IPG P-type:IPG A-type ratio correlated with a rise in the HbA1 (indicative of impaired glycemic control), with increased systolic blood pressure and increased obesity, all factors linked to Syndrome X. There was a parallism between the profile of the IPG P-type:IPG A-type ratio and the well-established pattern of insulin resistance and BMI, In vitro studies of the effects of alterations in the IPG P-type:IPG A-type ratio on the activation of the pyruvate dehydrogenase complex (PDH complex) at the PDH phosphatase reaction demonstrated that IPG A-type forms antagonized the stimulation of the PDH phosphatase by IPG P-type forms, thus having a negative effect on the conversion of PDH to the active, dephosphorylated, form. This observation could provide a mechanism whereby the shifts in the IPG P-type:IPG A-type ratio reported above could change the metabolic pattern from one directed to glucose oxidation to one more directed toward energy conservation and lipid storage, (C) 1999 Academic Press.