ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) ASSOCIATED WITH TRANSFUSIONS
ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) ASSOCIATED WITH TRANSFUSIONS
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DOI：
10.1056/nejm198401123100201
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发表时间：
1984-01-01
影响因子：
158.5
通讯作者：
EVATT, BL
中科院分区：
文献类型：
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作者：
CURRAN, JW;LAWRENCE, DN;EVATT, BL
在疾病预防控制中心1983年8月22日报告的2157例获得性免疫缺陷综合征(AIDS)患者中，(3%)的艾滋病和卡氏肺孢子虫肺炎没有公认的艾滋病危险因素。其中18人(28%)在发病前5年内接受过血液成分治疗。这些与输血相关的艾滋病患者比其他没有已知危险因素的患者更有可能是白人(P=0.00008)和年龄更大(P=0.0013)的患者。采血时间15~57mo。(中位数，27.5)在艾滋病确诊前，捐赠者从2人到48人(中位数，14人)。在7例完成供者调查的病例中，通过访谈或T细胞亚群分析，每例至少发现1例高危供者；访谈中发现的6例高危供者中，有5例T细胞辅助者/抑制者比例低，4例根据病史或检查有全身性淋巴结病。因此，艾滋病可能会通过血液传播。
Of 2157 patients with the acquired immunodeficiency syndrome (AIDS) whose cases were reported to the Centers for Disease Control by August 22, 1983, 64 (3%) with AIDS and Pneumocystis carinii pneumonia had no recognized risk factors for AIDS. Eighteen of these (28%) had received blood components within 5 yr before the onset of illness. These patients with transfusion-associated AIDS were more likely to be white (P = 0.00008) and older (P = 0.0013) than other patients with no known risk factors. They had received blood 15 to 57 mo. (median, 27.5) before the diagnosis of AIDS, from 2 to 48 donors (median, 14). At least 1 high-risk donor was identified by interview or T-cell-subset analysis in each of the 7 cases in which investigation of the donors was complete; 5 of the 6 high-risk donors identified during interview also had low T-cell helper/suppressor ratios, and 4 had generalized lymphadenopathy according to history or examination. Thus, AIDS may be transmitted in blood.