Synthesis of a cyclic melanotropic peptide exhibiting both melanin-concentrating and -dispersing activities.
Synthesis of a cyclic melanotropic peptide exhibiting both melanin-concentrating and -dispersing activities.
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DOI：
10.1126/science.6609433
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发表时间：
1984-06
期刊：
影响因子：
56.9
通讯作者：
B. Wilkes;V. Hruby;A. M. Castrucci;W. C. Sherbrooke;M. Hadley
中科院分区：
文献类型：
--
作者：
B. Wilkes;V. Hruby;A. M. Castrucci;W. C. Sherbrooke;M. Hadley
合成了一种假定的黑色素浓缩激素。这种肽，H-Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val-OH，在纳摩尔浓度下刺激硬骨鱼黑素细胞内黑色素颗粒聚集，就像天然纯化的硬骨鱼垂体制剂一样。此外，这种肽还能刺激青蛙和蜥蜴黑素细胞内黑色素颗粒的分散。该肽对青蛙和蜥蜴黑素细胞的活性约为α-黑素细胞刺激激素的六分之一，是一种完全激动剂。
A putative melanin-concentrating hormone was synthesized. This peptide, H-Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val-OH , stimulates melanin granule aggregation within teleost melanocytes at nanomolar concentrations as does the natural purified teleost pituitary preparation. In addition, this peptide stimulates melanin granule dispersion within melanocytes of frogs and lizards. The peptide has about one six-hundredth of the activity of alpha-melanocyte-stimulating hormone on frog and lizard melanocytes and is a full agonist.