Struggling behavior during restraint is regulated by stress experience
Struggling behavior during restraint is regulated by stress experience
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DOI：
10.1016/j.bbr.2008.03.030
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发表时间：
2008-08-22
影响因子：
2.7
通讯作者：
Bhatnagar, Seema
中科院分区：
文献类型：
--
作者：
Grissom, Nicola;Kerr, Wesley;Bhatnagar, Seema
约束会引发许多生理应激反应，这些反应的强度可以根据之前的应激历史而增加或减少。例如，反复受到束缚会导致下丘脑-垂体-肾上腺（HPA）激活对束缚的习惯。相反，在不同的重复压力源之后的急性抑制会促进 HPA 活性对新压力的影响。急性约束也会引发各种行为，包括挣扎，但先前的压力在调节对约束的行为反应方面的作用尚不清楚。本研究的目的是评估在有或没有重复压力史的情况下在约束期间的挣扎。使用自动行为分析软件（EthoVision），我们量化了约束期间的挣扎。我们发现，受到严重束缚的老鼠表现出剧烈的挣扎行为，但在单次束缚期间这种行为有所下降。反复的束缚会导致习惯性的挣扎行为，而反复游泳后的急性束缚会引发挣扎行为。这些对挣扎的影响与 HPA 活动的预期差异一起被发现。通过肾上腺切除术消除压力引起的皮质酮增加并没有显着影响对约束的挣扎反应。总体而言，约束引起的挣扎似乎以类似于 HPA 对约束的反应的方式进行调节，但不受肾上腺激素的控制。 (C) 2008 Elsevier B.V. 保留所有权利。
Restraint elicits a number of physiological stress responses that can be increased or decreased in magnitude based on prior stress history. For instance, repeated exposure to restraint leads to habituation of hypothalamic-pituitary-adrenal (HPA) activation to restraint. In contrast, acute restraint after a different repeated stressor leads to facilitation of HPA activity to the novel stress. Acute restraint also elicits a variety of behaviors, including struggling, but the effect of prior stress in regulating behavioral responses to restraint is not clear. The goal of the present studies was to assess struggling during restraint with or without a prior history of repeated stress. Using automated behavioral analysis software (EthoVision), we quantified struggling during restraint. We found that acutely restrained rats exhibited vigorous struggling behavior that declined during a single restraint period. Repeated restraint lead to habituated struggling behavior, whereas acute restraint after repeated swim elicited facilitated struggling behavior. These effects on struggling were found alongside expected differences in HPA activity. Removing stress-induced increases in corticosterone via adrenalectomy did not significantly affect struggling responses to restraint. Overall, restraint-induced struggling appears to be regulated in a manner similar to HPA responses to restraint, but is not dictated by adrenal hormones. (C) 2008 Elsevier B.V. All rights reserved.