Conversion of glycerol to glucose in the normal dog.
Conversion of glycerol to glucose in the normal dog.
复制标题
正常狗体内甘油转化为葡萄糖。
DOI：
--
复制
发表时间：
1970
影响因子：
--
通讯作者：
N. Altszuler
中科院分区：
文献类型：
--
作者：
B. Winkler;I. Rathgeb;R. Steele;N. Altszuler
温克勒，B.，I.卡瑟格布河STEELE，和N.阿尔祖勒。甘油在正常犬中转化为葡萄糖。Am. J. Physiol.219（2）：497-502. 1970.-在吸收后状态的未麻醉犬中测量血液甘油碳转化为血糖碳的速率，该过程由肝脏进行。速率的计算需要了解葡萄糖和甘油周转的单独速率;这些速率是用葡萄糖-61 *C和甘油-U-1 *C测量的，静脉输注微量。当同时使用两种标记的化合物时，制备血浆葡萄糖的两种单独的衍生物，以区分由输注的葡萄糖-6J4C引起的I *C和由甘油转化为葡萄糖引起的I *C。在平均浓度（吸收后状态）为0.12 mM时，从血浆中摄取的甘油为7.6 mmol/m2体表面积/hr。在摄取的甘油碳中，34 y 0作为葡萄糖碳迅速返回血液;这占释放到血液中的总葡萄糖碳的6.30/。当注入大量甘油以增加（高达四倍）正常甘油摄取率时，葡萄糖释放率并没有增加;与之前吸收的甘油碳转化为葡萄糖碳的比例大致相同，但现在这占总葡萄糖碳释放量的30 y 0。
WINKLER, B., I. KATHGEB, R. STEELE, AND N. ALTSZULER. Conversion of glycerol to glucose in the normal dog. Am. J. Physiol. 219(2) : 497-502. 1970.-Rates of conversion of blood glycerol carbon to blood glucose carbon, a process carried out by the liver, were measured in unanesthetized dogs in the postabsorptive state. The calculation of the rates required knowledge of the separate rates of glucose and glycerol turnover; those were measured with glucose-6l*C and glycerol-U-l*C, infused intravenously in trace amounts. When both tagged compounds were used simultaneously, two separate derivatives of plasma glucose were prepared in order to differentiate between l*C arising from infused glucose-6J4C and l*C arising from the conversion of glycerol to glucose. Uptake of glycerol from the plasma at the mean concentration (postabsorptive state) of 0.12 mM was 7.6 mmoles/m2 body surface area per hr. Of the glycerol carbon taken up, 34y0 was returned promptly to the blood as glucose carbon; this accounted for 6.30/, of the total glucose carbon released to the blood. When bulk glycerol was infused to increase (up to fourfold) the normal glycerol uptake rate, the rate of glucose release did not increase; about the same fraction as before of the glycerol carbon taken up was converted to glucose carbon, but this now accounted for up to 30y0 of the total glucose carbon released.