REM sleep enhancement by bupropion in depressed men.
REM sleep enhancement by bupropion in depressed men.
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安非他酮可增强抑郁男性的快速眼动睡眠。
DOI：
10.1176/ajp.152.2.274
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Kupfer,DJ
中科院分区：
文献类型：
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作者：
Nofzinger,EA;Reynolds3rd,CF;Thase,ME;Frank,E;Jennings,JR;Fasiczka,AL;Sullivan,LR;Kupfer,DJ
目的比较安非他酮、氟西汀和认知行为疗法对抑郁症患者脑电睡眠的影响。方法18例抑郁症患者，随机分为安非他酮组(7例)和氟西汀组(11例)，分别在治疗前和部分或完全缓解后进行整夜睡眠脑电检查。通过汉密尔顿抑郁量表评分的变化来衡量对这些药物的反应。18名年龄和汉密尔顿抑郁量表评分相匹配的男性接受认知行为治疗前后的脑电睡眠研究结果，36名未患抑郁症的男性接受一次性脑电睡眠测量。结果服用安非他酮的抑郁症患者治疗后REM潜伏期缩短，REM睡眠百分比和REM时间增加。这些效果与氟西汀和认知行为疗法的效果形成对比。结论本研究首次报道了一种能缩短快速眼动潜伏期和增加快速眼动睡眠的抗抑郁药物。如果得到证实，这一发现可能需要修改我们目前对抑郁、快速眼动睡眠和抗抑郁机制之间关系的理解。
ObjectiveThe authors compared the effects of bupropion, fluoxetine, and cognitive behavior therapy on EEG sleep in depressed subjects.MethodAll-night sleep EEG studies were performed before treatment and after partial or full remission on 18 men with depression diagnosed according to Research Diagnostic Criteria and randomly assigned to treatment with either bupropion (N= 7) or fluoxetine (N= 11). Response to these drugs was measured by changes in Hamilton Depression Rating Scale scores. Pre-and posttreatment EEG sleep study results before and after treatment with cognitive behavior therapy were also available for 18 men matched in age and severity of Hamilton depression scale score, and one-time EEG sleep measures were available for 36 men who were not depressed.ResultsREM latency was reduced and REM sleep percent and REM time increased after treatment in the depressed men given bupropion. These effects contrasted with the effects of fluoxetine and cognitive behavior therapy.ConclusionsThis study represents the first report of an antidepressant medication that shortens REM latency and increases REM sleep. If confirmed, this finding may require a revision of our current understanding of the relation among depression, REM sleep, and anti-depressant mechanisms.