Steady state visual evoked potential abnormalities in schizophrenia
Steady state visual evoked potential abnormalities in schizophrenia
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DOI：
10.1016/j.clinph.2004.09.016
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发表时间：
2005-03-01
影响因子：
4.7
通讯作者：
O'Donnell, BF
中科院分区：
文献类型：
--
作者：
Krishnan, GP;Vohs, JL;O'Donnell, BF
目的：稳态视觉诱发电位（SSVEP）可用于测试神经回路的频率响应函数。先前的研究表明，精神分裂症患者的ssvep降低至α，刺激频率降低。我们在theta （4hz）到gamma （40hz）的频率范围内研究了精神分裂症患者的ssvep。方法：18例精神分裂症患者和33例健康对照者在4、8、17、20、23、30、40 Hz 7种不同频率刺激下的ssvep。用激励频率下的功率（信号功率）和高于或低于激励频率的功率（噪声功率）来量化SSVEP的响应。结果：两组小鼠的刺激强度与频率呈反比关系。与健康对照组相比，精神分裂症受试者在较高频率（高于17 Hz）下表现出较低的信号功率，但在枕区4和8 Hz时表现出较低的信号功率。精神分裂症受试者枕区4 ~ 20 Hz频率和额区4、17 ~ 20 Hz频率的噪声功率较高。结论：精神分裂症患者在β和γ刺激频率下SSVEP信号功率降低。精神分裂症受试者在beta和较低频率的光刺激下表现出较高水平的脑电图噪声。意义：神经网络不能产生或维持振荡可能导致精神分裂症患者视觉加工缺陷。(c) 2004年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: The steady state visual evoked potential (SSVEP) can be used to test the frequency response function of neural circuits. Previous studies have shown reduced SSVEPs to alpha and lower frequencies of stimulation in schizophrenia. We investigated SSVEPs in schizophrenia at frequencies spanning the theta (4 Hz) to gamma (40 Hz) range.Methods: The SSVEPs to seven different frequencies of stimulation (4, 8, 17, 20, 23, 30 and 40 Hz) were obtained from 18 schizophrenia subjects and 33 healthy control subjects. Power at stimulating frequency (signal power) and power at frequencies above and below the stimulating frequency (noise power) were used to quantify the SSVEP responses.Results: Both groups showed an inverse relationship between power and frequency of stimulation. Schizophrenia subjects showed reduced signal power compared to healthy control subjects at higher frequencies (above 17 Hz), but not at 4 and 8 Hz at occipital region. Noise power was higher in schizophrenia subjects at frequencies between 4 and 20 Hz over occipital region and at 4, 17 and 20 Hz over frontal region.Conclusions: SSVEP signal power at beta and gamma frequencies of stimulation were reduced in schizophrenia. Schizophrenia subjects showed higher levels of EEG noise during photic stimulation at beta and lower frequencies.Significance: Inability to generate or maintain oscillations in neural networks may contribute to deficits in visual processing in schizophrenia. (c) 2004 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.