VEGF and M-CSF levels in periodontal tissue during tooth movement
VEGF and M-CSF levels in periodontal tissue during tooth movement
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DOI：
10.2220/biomedres.29.181
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发表时间：
2008-08-01
影响因子：
1.2
通讯作者：
Tanne, Kazuo
中科院分区：
文献类型：
--
作者：
Kaku, Masato;Motokawa, Masahide;Tanne, Kazuo
已有研究表明，血管内皮生长因子（VEGF）和巨噬细胞集落刺激因子（M-CSF）均可诱导破骨细胞募集。因此，认为VEGF和M-CSF密切参与骨重建过程。本研究旨在探讨正畸治疗过程中VEGF和M-CSF表达的变化。采用原位杂交技术检测小鼠实验性牙齿移动过程中成骨细胞和成纤维细胞中VEGF和M-CSF mRNA的表达。此外，正畸患者的尖牙回缩侧和对照侧进行了比较，揭示了在统计学上显着增加的VEGF和M-CSF的浓度在龈沟液。这些结果表明，正畸牙齿移动导致VEGF和M-CSF水平的增加。这些因素可能通过骨细胞骨吸收诱导骨重建。
It has been reported that both vascular endothelial growth factor (VEGF) and macrophage colony-stimulating factor (M-CSF) can induce osteoclast recruitment. Thus, VEGF and M-CSF are considered to be closely involved in the bone remodeling process. The purpose of this study was to evaluate changes in VEGF and M-CSF expression during orthodontic treatment. The expression of VEGF and M-CSF mRNA in osteoblasts and fibroblasts was detected by in situ hybridization during experimental tooth movement in mice. Furthermore, the canine retraction side and the control side of orthodontic patients were compared, revealing a statistically significant increase in both VEGF and M-CSF concentrations in gingival crevicular fluid. These results suggest that orthodontic tooth movement causes an increase in VEGF and M-CSF levels. These factors may induce bone remodeling via osteoclastic bone resorption.