Nanocarriers in advanced drug targeting: setting novel paradigm in cancer therapeutics
Nanocarriers in advanced drug targeting: setting novel paradigm in cancer therapeutics
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DOI：
10.1080/21691401.2017.1366333
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发表时间：
2018-01-01
影响因子：
5.8
通讯作者：
Amin, Saima
中科院分区：
文献类型：
--
作者：
Akhter, Md. Habban;Rizwanullah, Md.;Amin, Saima
癌症日益增多，因此全球范围内的死亡人数居高不下。医疗干预包括化疗、放射治疗和手术切除。这种常规技术缺乏靶向能力，对正常细胞造成伤害。在药物治疗方案中，联合治疗方案优于单一药物治疗模块，因为化疗药物在癌细胞中的内在化程度更高，既可以增强渗透保留效应，又可以直接诱导细胞凋亡。癌症疗法涉及到将活性部分输送到靶点的不同方法。化疗靶向的主动和被动转运模式利用先进的纳米载体。应用先进的纳米载体的纳米技术战略治疗极大地有助于缓解癌症的流行。针对特定区域的纳米载体纳米地毯吸引了全球科学家，并在这方面提出了需要解决的问题。因此，各种技术和方法应运而生，以满足这些目标。随着纳米药物和药物释放的进展，本文简要介绍了纳米药物的各种给药方式，包括纳米粒、脂质体、树枝状大分子、量子点、碳纳米管、金属纳米粒、纳米脂载体(NLC)、金纳米壳、纳米悬臂梁和纳米线，它们在癌症治疗中具有广阔的应用前景。
Cancer has been growing nowadays consequently high number of death ascertained worldwide. The medical intervention involves chemotherapy, radiation therapy and surgical removal. This conventional technique lacking targeting potential and harm the normal cells. In drug treatment regimen, the combination therapy is preferred than single drug treatment module due to higher internalization of chemotherapeutics in the cancer cells both by enhance permeation retention effect and by direct cell apoptosis. The cancer therapeutics involves different methodologies of delivering active moiety to the target site. The active and passive transport mode of chemotherapeutic targeting utilizes advance nanocarriers. The nanotechnological strategic treatment applying advance nanocarrier greatly helps in mitigating the cancer prevalence. The nanocarrier-incorporating nanodrug directed for specific area appealed scientist across the globe and issues to be addressed in this regard. Therefore, various techniques and approaches invented to meet the objectives. With the advances in nanomedicine and drug delivery, this review briefly focused on various modes of nanodrug delivery including nanoparticles, liposomes, dendrimer, quantum dots, carbon nanotubes, metallic nanoparticles, nanolipid carrier (NLC), gold nanoshell, nanosize cantilevers and nanowire that looks promising and generates a novel horizon in cancer therapeutics.