Developmental profiles of infant EEG: overlap with transient cortical circuits.
Developmental profiles of infant EEG: overlap with transient cortical circuits.
复制标题
婴儿脑电图的发育概况：与瞬态皮层回路重叠。
DOI：
10.1016/j.clinph.2011.11.264
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Stark,RI
中科院分区：
文献类型：
--
作者：
Myers,MM;Grieve,PG;Izraelit,A;Fifer,WP;Isler,JR;Darnall,RA;Stark,RI
为了量化在人类早期发育过程中EEG中频率特异性频带和通常观察到的爆发活动类型中的频谱功率，使用功率谱分析和高频爆发检测算法分析了在先前的多中心研究中获得的来自月经后35至52周的人类婴儿的EEG数据的广泛存档。高频功率则从35周下降到45周。这种意外的减少主要归因于高频爆发的数量迅速下降。结论高频爆发活动的下降与GABA对神经元的作用从去极化到超极化的发育转变以及皮层亚板的差距连接电路的溶解相重叠。跟踪对大脑功能正常发育至关重要的特定神经生理机制的变化。
OBJECTIVETo quantify spectral power in frequency specific bands and commonly observed types of bursting activities in the EEG during early human development.METHODSAn extensive archive of EEG data from human infants from 35 to 52weeks postmenstrual age obtained in a prior multi-center study was analyzed using power spectrum analyses and a high frequency burst detection algorithm.RESULTSLow frequency power increased with age; however, high frequency power decreased from 35 to 45weeks. This unexpected decrease was largely attributable to a rapid decline in the number of high frequency bursts.CONCLUSIONSThe decline in high frequency bursting activity overlaps with a developmental shift in GABA’s actions on neurons from depolarizing to hyperpolarizing and the dissolution of the gap junction circuitry of the cortical subplate.SIGNIFICANCEWe postulate that quantitative characterization of features of the EEG unique to early development provide indices for tracking changes in specific neurophysiologic mechanisms that are critical for normal development of brain function.