Nuclear magnetic resonance-based analysis of urine for the rapid etiological diagnosis of pneumonia.
Nuclear magnetic resonance-based analysis of urine for the rapid etiological diagnosis of pneumonia.
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DOI：
10.1517/17530059.2011.537653
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Slupsky, Carolyn M
中科院分区：
文献类型：
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作者：
Slupsky, Carolyn M
外地的重要性：肺炎是一种急性下呼吸道感染性疾病，由于可能的病原体数量众多而难以诊断。目前，没有一个单一的测试能够快速确定肺炎的病因patients.Areas覆盖在这篇综述：本文回顾了目前的方法诊断肺炎的原因，并讨论了潜在的临床相关的代谢组学检测的发展。它还探讨了使用NMR光谱作为分析工具的可能性。读者将获得什么：读者将介绍代谢组学，因为它涉及到传染病，包括两个最近的文章代谢组学概况在肺炎以及NMR技术，以获得更好地了解这项技术的发展，因为它涉及到肺炎诊断领域。基于核磁共振的代谢组学可能有助于快速诊断肺炎的病因，并有可能成为一种重要的筛查方法。如果在更大规模的临床研究中得到证实，这种测试可能在临床上变得可行，并帮助医生确定最佳治疗方案，帮助监测治疗效果，并提供有价值的全球疾病监测信息。此外，传染病的代谢组学研究可以提供病原体感染模式的见解，并发现产生新类别药物的新方法。
IMPORTANCE OF THE FIELD: Pneumonia is an acute infectious illness of the lower respiratory tract that is difficult to diagnose owing to the large number of possible pathogens. At present there is no single test capable of rapidly determining the etiology of pneumonia in patients.AREAS COVERED IN THIS REVIEW: This article reviews current approaches for diagnosing the cause of pneumonia and discusses the potential for the development of clinically relevant metabolomics assays. It also examines the possibility of using NMR spectroscopy as an analytical tool for this application.WHAT THE READER WILL GAIN: The reader will be introduced to metabolomics as it pertains to infectious disease, including two recent articles on metabolomic profiles in pneumonia as well as NMR technology in order to gain a better understanding of the development of this technology as it pertains to the field of pneumonia diagnostics.TAKE HOME MESSAGE: NMR-based metabolomics may lend itself to rapid diagnosis of the etiology of pneumonia and has the potential to become an important screening method. If proven in larger clinical studies, this test may become feasible in the clinic and assist physicians with determining the best course of treatment, help with monitoring treatment efficacy, and provide valuable global disease surveillance information. Furthermore, metabolomics studies of infectious disease may provide insights into the mode of pathogen infection and uncover new approaches for generating new classes of pharmaceuticals.