RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders
RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders
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DOI：
10.1016/s0304-3940(03)00608-6
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发表时间：
2003-08-07
影响因子：
2.5
通讯作者：
Kato, T
中科院分区：
文献类型：
--
作者：
Iwamoto, K;Kato, T
对 HTR2C 缺陷小鼠的研究以及连锁和关联研究表明，血清素 2C 受体 (HTR2C) 在精神障碍中的重要性。最近的研究表明，HTR2C 的 RNA 编辑与精神障碍有关。在这里，我们通过使用引物延伸结合变性高效液相色谱检查了双相情感障碍、精神分裂症和重度抑郁症患者以及对照受试者的前额皮质样本中 HTR2C 位点 A 和 D 的 RNA 编辑效率。尸检样本由斯坦利基金会大脑收藏捐赠。我们没有发现患者体内这些位点的 RNA 编辑效率发生显着变化。然而，我们发现抑郁患者 D 位点（P = 0.08）和自杀受害者 A 位点（P = 0.07）的 RNA 编辑效率有增加的趋势。这些发现与之前的发现一致，表明 HTR2C RNA 编辑的改变可能对重度抑郁症和自杀具有一定意义。 (C) 2003 Elsevier Science Ireland Ltd. 保留所有权利。
The importance of serotonin 2C receptor (HTR2C) in mental disorders has been implicated by studies of HTR2C-deficient mice and linkage and association studies. Recent studies have revealed that RNA editing of HTR2C is involved in mental disorders. Here we examined RNA editing efficiencies of site A and D of HTR2C in the prefrontal cortex samples of patients with bipolar disorder, schizophrenia, and major depression as well as control subjects by using primer extension combined with denaturing high performance liquid chromatography. Postmortem samples were donated by the Stanley Foundation Brain Collection. We could not find significant alterations of RNA editing efficiencies of these sites in patients. However, we found trends for increased RNA editing efficiencies of site D in depressive patients (P = 0.08) and site A in suicide victims (P = 0.07). These findings are in accordance with the previous findings, and suggest that altered RNA editing of HTR2C may have some significance in major depression and suicide. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.