The presence of steroid receptors in "nontarget" tissues and its significance.
The presence of steroid receptors in "nontarget" tissues and its significance.
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“非目标”组织中类固醇受体的存在及其意义。
DOI：
10.1093/ajcp/99.2.120
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发表时间：
1993
影响因子：
3.5
通讯作者：
Kiang,DT
中科院分区：
文献类型：
--
作者：
Kiang,DT
It used to be simple, straightforward, and easily understood that sex hormones such as estrogens and progestins exert their function on target organs, namely, the uterus, breast, pituitary gland, and certain regions of the central nervous system that direct sexual development in the early embryonic stage. This concept is further substantiated by the findings that abundant amounts of intracellular estrogen receptors (ERs) and progesterone receptors (PRs) are present in these target tissues. After forming complexes with their respective ligands, receptors are capable of binding to hormone response elements on the DNA template and act like a transcription factor to transactivate the target genes related to reproductive functions.As the ER and PR assays became widely used, studies focused on tissues other than the conventional target organs, usually based on a common interest in searching for reasons behind many unexplained biological behaviors—for instance, why does acne frequently develop on the facial skin during puberty? This kind of curiosity led to the study of ER content in skin from various parts of the body. Indeed, the ER was found to be twice as concentrated in skin from the face than in that from the thigh and breast. 1 The rare disorder, pulmonary lymphangiomyomatosis, which used to be treated with hormonal manipulation in young women, was found to contain progesterone receptors. 2 Benign and malignant thyroid diseases are more common in females during their reproductive stage. In this
