Is there a receptor for dehydroepiandrosterone or dehydroepiandrosterone sulfate?
Is there a receptor for dehydroepiandrosterone or dehydroepiandrosterone sulfate?
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是否存在脱氢表雄酮或硫酸脱氢表雄酮受体？
DOI：
10.1055/s-2004-861546
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发表时间：
2004
影响因子：
2.7
通讯作者：
Dillon,JosephS
中科院分区：
文献类型：
--
作者：
Widstrom,RichardL;Dillon,JosephS
脱氢表雄酮(DHEA)和脱氢表雄酮硫酸酯(DHEAS)除了作为雄激素合成的代谢中间体外，是否还具有生理作用尚不清楚。除细胞内代谢外，脱氢表雄酮的生理浓度没有令人信服的细胞作用机制(S)。与其他主要类固醇不同，脱氢表雄酮的受体(S)尚未被明确分离。本文将回顾支持脱氢表雄酮直接生理效应的受体依赖基础的证据(S)。支持脱氢表雄酮(S)的细胞内受体的数据相对较弱，不允许我们确定脱氢表雄酮(S)是直接还是作为脱氢表雄酮(S)的代谢物起直接受体配体的作用。最近的数据强烈支持DHEA的质膜受体，但这一潜在的受体尚未被分离出来。在我们确定脱氢表雄酮(S)除了作为雄激素前体之外是否具有生物学作用之前，有必要确定脱氢表雄酮(S)作用的分子机制(受体或其他)。
It remains unknown whether dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) have a physiological role other than serving as metabolic intermediates in androgen synthesis. Apart from intracellular metabolism, there is no convincing cellular mechanism of action for physiological concentrations of DHEA (S). Unlike other major steroids, a receptor for DHEA (S) has not been definitively isolated. This article will review the evidence supporting a receptor-dependent basis for the direct physiological effects of DHEA (S). The data supporting an intracellular receptor for DHEA (S) are relatively weak and do not allow us to determine whether DHEA (S) directly, or a metabolite of DHEA (S), acts as a direct receptor ligand. Recent data strongly support a plasma membrane receptor for DHEA, but this potential receptor is yet to be isolated. Definitive characterization of the molecular mechanism (receptor or otherwise) of DHEA (S) action is necessary before we can determine whether DHEA (S) has a biological role other than as an androgen precursor.