Ipilimumab-Induced Hypophysitis: MR Imaging Findings
Ipilimumab-Induced Hypophysitis: MR Imaging Findings
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DOI：
10.3174/ajnr.a1623
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发表时间：
2009-10-01
影响因子：
3.5
通讯作者：
Murtagh, F. R.
中科院分区：
文献类型：
--
作者：
Carpenter, K. J.;Murtagh, R. D.;Murtagh, F. R.
Ipilimumab是一种有前途的新型免疫抑制剂，在转移性黑色素瘤和肾细胞癌的治疗中具有临床活性。然而，随着免疫疗法的进步，出现了与这些药物的作用机制相关的许多新的副作用。在我们的机构，3例患者出现垂体炎，根据记录的药物与其他自身免疫现象的关系，将其归因于自身免疫过程，并在停药和添加类固醇后显著快速改善。我们提出的影像学表现在3例患者推测ipilimumab诱导垂体炎。
Ipilimumab is a promising new immunotherapeutic antineoplastic agent with clinical activity in the treatment of metastatic melanoma and renal cell carcinoma. With advances in immunotherapy, however, a host of new side effects related to the mechanism of action of these drugs has appeared. At our institution, 3 patients presented with hypophysitis, which was attributed to an autoimmune process based on the documented relationship of the drug to other autoimmune phenomena and significant and rapid improvement with discontinuation of the drug and addition of steroids. We present the imaging findings in 3 patients with presumed ipilimumab-induced hypophysitis.