Emerging molecular mediators and targets for age-related skeletal muscle atrophy.
Emerging molecular mediators and targets for age-related skeletal muscle atrophy.
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DOI：
10.1016/j.trsl.2020.03.001
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Brooks SV
中科院分区：
文献类型：
--
作者：
Brown LA;Guzman SD;Brooks SV
与年龄相关的肌肉质量下降已成为老年人身体虚弱的同义词，因为它在肌肉功能下降中起着重要作用。蛋白质和氧化还原稳态的改变沿着慢性炎症、去神经支配和激素失调都是肌肉萎缩的标志，并导致老年人的临床肌肉减少症。骨骼肌质量的减少已经在科学文献中观察和报道了近两个世纪;然而，识别和仔细检查与年龄相关的肌肉萎缩的分子介质只有大约三十年的时间。在这里，我们回顾了最近感兴趣的分子靶点在年龄相关的肌肉萎缩，并简要讨论了新兴的小分子治疗性治疗肌肉萎缩的易感人群。
The age-associated decline in muscle mass has become synonymous with physical frailty among the elderly due to its major contribution in reduced muscle function. Alterations in protein and redox homeostasis along with chronic inflammation, denervation and hormonal dysregulation are all hallmarks of muscle wasting and lead to clinical sarcopenia in older adults. Reduction in skeletal muscle mass has been observed and reported in the scientific literature for nearly two centuries; however, identification and careful examination of molecular mediators of age-related muscle atrophy have only been possible for roughly three decades. Here we review molecular targets of recent interest in age-related muscle atrophy and briefly discuss emerging small molecule therapeutic treatments for muscle wasting in sarcopenic susceptible populations.
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影响因子：
5.3
作者：
Barik, Arnab;Lu, Yisheng;Mei, Lin
通讯作者：
Mei, Lin
影响因子：
4.8
作者：
Buetikofer, Lukas;Zurlinden, Andreas;Sonderegger, Peter
通讯作者：
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影响因子：
4.8
作者：
Altun, Mikael;Besche, Henrike C.;Ulfhake, Brun
通讯作者：
Ulfhake, Brun
DOI：
10.1074/jbc.m116.740308
发表时间：
2016-08-19
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Bullard SA;Seo S;Schilling B;Dyle MC;Dierdorff JM;Ebert SM;DeLau AD;Gibson BW;Adams CM
通讯作者：
Adams CM
DOI：
10.18632/aging.100040
发表时间：
2009-04-20
期刊：
Aging
影响因子：
--
作者：
Blagosklonny MV;Hall MN
通讯作者：
Hall MN