FATTY INFILTRATION OF THE LIVER - QUANTIFICATION BY H-1 LOCALIZED MAGNETIC-RESONANCE SPECTROSCOPY AND COMPARISON WITH COMPUTED-TOMOGRAPHY
FATTY INFILTRATION OF THE LIVER - QUANTIFICATION BY H-1 LOCALIZED MAGNETIC-RESONANCE SPECTROSCOPY AND COMPARISON WITH COMPUTED-TOMOGRAPHY
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DOI：
10.1097/00004424-199304000-00006
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发表时间：
1993-04-01
影响因子：
6.7
通讯作者：
PALMA, LD
中科院分区：
文献类型：
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作者：
LONGO, R;RICCI, C;PALMA, LD
原理和说明。作者使用图像引导的H-1定位MR波谱评估弥漫性肝脂肪变性受试者的肝脏脂肪浸润程度，并将磁共振（MR）确定的脂肪分数与计算机断层扫描（CT）肝/脾密度比和组织学评估相关联。通过应用双自旋回波定位序列在1.5 T下进行MR测量。26例患者接受了MR和CT检查以及超声（US）引导下活检。此外，3名健康志愿者接受了MR检查。脂肪变性的严重程度通过以下指标进行评估：1）脂肪和总MR信号面积的比值; 2）肝脏和脾脏CT值的比值; 3）组织学评分。MR脂肪/脂肪加水信号比值与CT肝脏/脾脏密度值比值之间的线性相关有统计学意义。这两种技术与组织学评分相关性良好。水或脂肪T2值与脂肪变性的严重程度无显著相关性。H-1磁共振波谱允许无创估计肝脏脂肪含量。
RATIONALE AND OBJECTIVES. The authors evaluated the degree of fatty infiltration of the liver in subjects with diffuse fiver steatosis using image-guided H-1 localized MR spectroscopy and correlated the magnetic resonance (MR)-determined fat fraction with the computed tomography (CT) liver/spleen density ratio and histologic evaluation.METHODS. MR measurements were performed at 1.5 T by applying a double-spin-echo localization sequence. Twenty-six patients underwent MR and CT examinations and ultrasound (US)-guided biopsy. Additionally, three healthy volunteers underwent MR examination. Steatosis severity was estimated using 1) the ratio between fat and total MR signal areas; 2) the ratio between liver and spleen CT number; and 3) histologic score.RESULTS. The linear correlation between MR fat/fat-plus-water signal ratio and CT liver/spleen density values ratio is statistically significant. Both techniques correlate well with histologic score. No significant correlation exists between water or fat T2 Values and the severity of steatosis.CONCLUSIONS. H-1 MR spectroscopy allows a noninvasive estimate of the hepatic fat content.