Mechanisms of translational control in early development.
Mechanisms of translational control in early development.
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DOI：
10.1016/s0959-437x(96)80083-9
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发表时间：
1996-10
影响因子：
4
通讯作者：
G. Seydoux
中科院分区：
文献类型：
--
作者：
G. Seydoux
卵母细胞积累母体 mRNA 的嫁妆，为胚胎发生做准备。这些母体转录物保持休眠状态，直到卵子发生晚期或胚胎发生早期它们的翻译被激活。近年来，出现了三种作用于母体mRNA的翻译控制：细胞质多腺苷酸化的翻译激活、RNA定位的翻译激活和调节性翻译抑制。在每种情况下，翻译控制取决于反式作用因子与 3' 非翻译区 (3'UTR) 中序列的结合。这些反式作用因子的鉴定开始揭示介导翻译控制的分子机制。
Oocytes accumulate a dowry of maternal mRNAs in preparation for embryogenesis. These maternal transcripts are kept dormant until late oogenesis or early embryogenesis when their translation is activated. In recent years, three types of translational control acting on maternal mRNAs have emerged: translational activation by cytoplasmic polyadenylation, translational activation by RNA localization, and regulated translational repression. In each case, translational control depends on the binding of trans-acting factors to sequences in the 3′ untranslated region (3′UTR). Identification of these trans-acting factors is beginning to shed light on the molecular mechanisms that mediate translational control.