Effect of length of time from diagnosis to treatment on colorectal cancer survival: A population-based study
Effect of length of time from diagnosis to treatment on colorectal cancer survival: A population-based study
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DOI：
10.1371/journal.pone.0210465
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发表时间：
2019-01-14
期刊：
影响因子：
3.7
通讯作者：
Tsai, Wen-Chen
中科院分区：
文献类型：
--
作者：
Lee, Yung-Heng;Kung, Pei-Tseng;Tsai, Wen-Chen
关于诊断到治疗间隔 (DTI) 对结直肠癌 (CRC) 患者生存率影响的证据有限。此外，之前关于治疗延迟和结直肠癌生存率的研究主要将所有阶段（I-IV）的患者分为一个队列。我们的研究对每个阶段进行了单独分析。我们对 2004 年至 2010 年从台湾癌症登记数据库中获得的 39,000 名新诊断的 CRC 患者进行了一项回顾性队列研究，以检查 DTI 对总体生存率的影响。 DTI 分为 3 组： = 151 天 (1,252, 3.15%)。与 DTI 75、查尔森合并症指数 >= 7、其他灾难性疾病、缺乏多学科团队参与以及在低容量中心治疗相比，DTI 31-150 天（风险比 1.51；95% 置信区间 1.43-1.59）和 DTI >= 151 天（1.64；1.54-1.76）的死亡风险增加。根据这些结果，我们建议所有 CRC 患者的 DTI，无论癌症分期如何，都应为 30 天或更短。
Evidence is limited regarding the effect of diagnosis-to-treatment interval (DTI) on the survival of colorectal cancer (CRC) patients. In addition, previous studies on treatment delay and CRC survival have largely grouped patients from all stages (I-IV) into one cohort. Our study provides analysis on each stage individually. We conducted a retrospective cohort study with 39,000 newly diagnosed CRC patients obtained from the Taiwan Cancer Registry Database from 2004-2010 to examine the effect of DTIs on overall survival. DTIs were divided into 3 groups: = 151 days (1,252, 3.15%). Risk of death was increased for DTI 31-150 days (hazard ratio 1.51; 95% confidence interval 1.43-1.59) and DTI >= 151 days (1.64; 1.54-1.76) compared to DTI 75, Charlson Comorbidity Index >= 7, other catastrophic illnesses, lack of multidisciplinary team involvement, and treatment in a low volume center. From these results, we advise that the DTI for all CRC patients, regardless of cancer staging, should be 30 days or less.