Dynamic Social Adaptation of Motion-Related Neurons in Primate Parietal Cortex
Dynamic Social Adaptation of Motion-Related Neurons in Primate Parietal Cortex
复制标题
DOI：
10.1371/journal.pone.0000397
复制
发表时间：
2007-04-25
期刊：
影响因子：
3.7
通讯作者：
Iriki, Atsushi
中科院分区：
文献类型：
--
作者：
Fujii, Naotaka;Hihara, Sayaka;Iriki, Atsushi
社交脑功能使我们能够使我们的行为适应社会环境，但由于技术限制，在单细胞水平上对它的了解很少。但其中涉及的问题是至关重要的：神经元如何识别和调节它们的活动以应对社会环境？为了探索其中的机制，我们开发了一种新的记录技术，称为多维记录，并将其同时应用于两只猴子的左顶叶皮层，而它们共享一个共同的社会空间。当猴子们坐得很近但没有互动时，每只猴子的顶叶活动都表现出对自己右臂动作的强烈反应偏好，而对另一只手臂的动作几乎没有反应。但是，如果猴子之间出现社会冲突，这种偏好就会被打破--特别是，如果两只猴子都能伸手去拿放在它们之间桌子上的同一种食物。在这种情况下，顶叶神经元开始对自我和他人的运动表现出复杂的组合反应。顶叶皮层通过丢弃和招募不同的神经群体来适应社会背景下的反应特性。我们的研究结果表明，顶叶神经元可以识别与当前社会背景相关的环境中的社会事件，并形成更大的社会大脑网络的一部分。
Social brain function, which allows us to adapt our behavior to social context, is poorly understood at the single-cell level due largely to technical limitations. But the questions involved are vital: How do neurons recognize and modulate their activity in response to social context? To probe the mechanisms involved, we developed a novel recording technique, called multi-dimensional recording, and applied it simultaneously in the left parietal cortices of two monkeys while they shared a common social space. When the monkeys sat near each other but did not interact, each monkey's parietal activity showed robust response preference to action by his own right arm and almost no response to action by the other's arm. But the preference was broken if social conflict emerged between the monkeys-specifically, if both were able to reach for the same food item placed on the table between them. Under these circumstances, parietal neurons started to show complex combinatorial responses to motion of self and other. Parietal cortex adapted its response properties in the social context by discarding and recruiting different neural populations. Our results suggest that parietal neurons can recognize social events in the environment linked with current social context and form part of a larger social brain network.