Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response
Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response
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DOI：
10.4049/jimmunol.169.3.1277
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发表时间：
2002-08-01
影响因子：
4.4
通讯作者：
Manz, RA
中科院分区：
文献类型：
--
作者：
Hauser, AE;Debes, GF;Manz, RA
在记忆免疫应答期间形成的浆母细胞从脾迁移到骨髓中并迁移到慢性炎症组织中，在那里它们分化成长寿命的浆细胞。在这项研究中，我们分析了用OVA二次免疫后形成的血浆母细胞的趋化因子反应性。从第4天开始，在大约48小时内，OVA特异性血浆母细胞从脾中移出并出现在骨髓中。虽然这些迁移细胞已经失去了对许多B细胞吸引趋化因子的反应性，CXC趋化因子配体（CXCL）13（B淋巴细胞化学引诱物），它们向CXCL 12（基质细胞衍生因子1 α）和炎性趋化因子CXCL 9（IFN-γ诱导的单核细胞因子）、CXCL 10（IFN-γ诱导蛋白10）和CXCL 11（IFN-诱导T细胞α化学引诱物）迁移。然而，血浆母细胞对这些趋化因子的反应性仅限于它们从脾移出后的几天，表明这些分子及其同源受体的作用，即，CXCR 3和CXCR 4在调节血浆原始细胞迁移到骨髓和/或发炎组织中的作用。
Plasma blasts formed during memory immune responses emigrate from the spleen to migrate into the bone marrow and into chronically inflamed tissues where they differentiate into long-lived plasma cells. In this study, we analyze the chemokine responsiveness of plasma blasts formed after secondary immunization with OVA. Starting from day 4 and within similar to48 h, OVA-specific plasma blasts emigrate from spleen and appear in the bone marrow. Although these migratory cells have lost their responsiveness to many B cell attracting chemokines, e.g., CXC chemokine ligand (CXCL)13 (B lymphocyte chemoattractant), they migrate toward CXCL12 (stromal cell-derived factor 1alpha), and toward the inflammatory chemokines CXCL9 (monokine induced by IFN-gamma), CXCL10 (IFN-gamma-inducible protein 10), and CXCL11 (IFN-inducible T cell alpha chemoattractant). However, the responsiveness of plasma blasts to these chemokines is restricted to a few days after their emigration from the spleen, indicating a role for these molecules and their cognate receptors, i.e., CXCR3 and CXCR4, in the regulation of plasma blast migration into the bone marrow and/or inflamed tissues.