Lack of patient education is risk factor of disease flare in patients with systemic lupus erythematosus in China
Lack of patient education is risk factor of disease flare in patients with systemic lupus erythematosus in China
复制标题
缺乏患者教育是中国系统性红斑狼疮患者疾病复发的危险因素
DOI：
10.1186/s12913-019-4206-y
复制
发表时间：
2019-06-13
影响因子：
2.8
通讯作者：
Jiang, Anli
中科院分区：
文献类型：
--
作者：
Zhang, Le;Luan, Wei;Jiang, Anli
背景：探讨中国系统性红斑狼疮（SLE）患者医疗服务的不足及其对临床结局的影响。
方法：2017年1月至2018年1月期间随机招募了210例SLE患者。每位患者接受自填式问卷调查，以评估用药依从性[风湿病依从性问卷（CQR）]、对药物的信念[药物信念问卷（BMQ）]以及对药物信息的满意度[药物信息满意度量表（SIMS）]。通过多因素逻辑回归分析SLE疾病活动指数（SLEDAI - 2K）与观察因素之间的关联。
结果：根据CQR，仅有28.10%的患者依从性良好。BMQ得分为2.85±5.42，仅有32.38%的患者对其处方药信息满意。疾病活动与SIMS、欧洲五维健康量表（EQ5D）、国际系统性红斑狼疮临床协作组（SLICC）、抑郁、非甾体抗炎药（NSAID）的使用相关（P<0.05）。疾病缓解与SIMS（比值比=0.16，95%置信区间：[0.06, 0.40]）和BMQ（比值比=0.64，95%置信区间：[0.43, 0.94]）呈正相关。
结论：在本研究中，BMQ和SIMS得分较低，这意味着医疗服务系统在患者教育方面存在缺陷，导致中国SLE患者疾病发作。
试验注册：ClinicalTrials.gov编号：NCT03024307。注册于2017年1月18日。
BackgroundTo explore the inadequacies of health service and its impact on clinical outcomes of patients with systemic lupus erythematosus (SLE) in China.MethodsA total of 210 SLE patients were randomly recruited between January 2017 and January 2018. Each patient received self-report questionnaires to assess medication adherence [Compliance Questionnaire for Rheumatology (CQR)], beliefs about medicines [Beliefs about Medicines Questionnaire (BMQ)] and satisfaction about medicine information [the Satisfaction with Information about Medicines Scale (SIMS)]. Associations between SLE disease activity index (SLEDAI-2 K) and observed factors were analyzed by multiple logistic regression.ResultsBased on CQR, only 28.10% patients were adherent. The score of BMQ was 2.85 ± 5.42, and merely 32.38% patients were satisfied with the information about their prescribed medicines. Disease activity was associated with SIMS, EuroQol five-dimensions [EQ5D], Systemic Lupus International Collaborating Clinics (SLICC), depression, use of NSAID (P≤ 0.05). Remission of disease was positively correlated with SIMS (OR = 0.16, 95% CI: [0.06, 0.40]), and BMQ (OR = 0.64, 95%CI: [0.43, 0.94]).ConclusionIn this study, the scores of BMQ and SIMS were low, implying defects in the patient education of health service system, which led to disease flare in Chinese SLE patients.Trial registrationClinicalTrials.gov ID: NCT03024307 . Registered January 18, 2017.