Age of Onset of Cannabis Use Is Associated With Age of Onset of High-Risk Symptoms for Psychosis
Age of Onset of Cannabis Use Is Associated With Age of Onset of High-Risk Symptoms for Psychosis
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DOI：
10.1177/070674371005500308
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发表时间：
2010-03-01
影响因子：
4
通讯作者：
Linszen, Don H.
中科院分区：
文献类型：
--
作者：
Dragt, Sara;Nieman, Dorien H.;Linszen, Don H.
目的：过去十年来，人们对精神分裂症前驱阶段的兴趣日益浓厚，促使我们开展研究，以监测罹患精神病的高风险人群。我们假设年轻时使用大麻或大麻使用障碍与年轻时的高风险症状有关。 方法：对转诊至荷兰阿姆斯特丹学术医疗中心的精神病超高风险 (UHR) 患者进行综合国际诊断访谈采访，以评估他们的大麻消费情况。精神分裂症发病回顾性评估访谈用于收集有关高危或前驱症状发病年龄的数据。选择九种高风险症状并进行聚类，因为它们与大麻使用有已知的关系。结果：在 68 名参与者中，35 人曾使用过大麻（51.5%），其中 15 人最近使用过大麻。 22 名参与者过去曾经滥用过大麻或依赖大麻（32.4%）。吸食大麻的年轻年龄与一系列症状的年轻发病年龄相关（rho = 0.48，P = 0.003），也与单独的 6 种症状相关（rho = 0.47 至 0.90，P < 0.001 至 0.04）。大麻使用障碍的发病年龄较年轻与一系列症状的发病年龄较年轻相关（rho = 0.67，P = 0.001），也与单独的 6 个症状相关（rho = 0.50 至 0.93，P = 0.007 至 0.03）。结论：在 UHR 群体中，大麻使用或较年轻的大麻使用障碍过渡到精神病与以下症状的发病有关：年轻时出现精神病的高危症状。
Objective: Increasing interest in the prodromal stage of schizophrenia over the past decade led us to perform our study to monitor people at high risk for developing a psychosis. We hypothesized that cannabis use or a cannabis use disorder at a younger age relates to high-risk symptoms at a younger age.Method: People referred to the Academic Medical Centre in Amsterdam, the Netherlands, with an ultra-high risk (UHR) for psychosis were interviewed with the Composite International Diagnostic Interview to assess their cannabis consumption. The Interview for the Retrospective Assessment of the Onset of Schizophrenia was used to collect data about age of onset of high-risk or prodromal symptoms. Nine high-risk symptoms were selected and clustered because of their known relation with cannabis use.Results: Among the 68 included participants, 35 had used cannabis (51.5%), of whom 15 had used recently. Twenty-two participants had been cannabis abusers or cannabis-dependent (32.4%) in the past. Younger age at onset of cannabis use was related to younger age of onset of the cluster of symptoms (rho = 0.48, P = 0.003) and also to 6 symptoms individually (rho = 0.47 to 0.90, P < 0.001 to 0.04). Younger age at onset of a cannabis use disorder was related to younger age of onset of the cluster of symptoms (rho = 0.67, P = 0.001) and also to 6 symptoms individually (rho = 0.50 to 0.93, P = 0.007 to 0.03).Conclusion: Cannabis use or a cannabis use disorder at a younger age in a group with an UHR for transition to psychosis is related to onset of high-risk symptoms for psychosis at a younger age.