The effect of estrogen use on levels of glucose and insulin and the risk of type 2 diabetes in American Indian postmenopausal women - The Strong Heart Study
The effect of estrogen use on levels of glucose and insulin and the risk of type 2 diabetes in American Indian postmenopausal women - The Strong Heart Study
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DOI：
10.2337/diacare.25.3.500
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发表时间：
2002-03-01
期刊：
影响因子：
16.2
通讯作者：
Lee, ET
中科院分区：
文献类型：
--
作者：
Zhang, Y;Schaefer, CF;Lee, ET
目的-检查雌激素使用与胰岛素和葡萄糖水平之间的相关性，以及雌激素使用对2型糖尿病风险的影响。研究设计和方法-本报告基于857名非糖尿病和绝经后女性基线检查（1989-1992年），平均4年后完成第二次考试（1993-1995年）。参与者被分为三组;从未，过去和当前用户根据他们的基线雌激素使用状态。采用协方差分析比较雌激素使用组之间的胰岛素和血糖水平。Logistic回归被用来评估雌激素的使用和2型diabetes.Results的发病率之间的关联-绝经后雌激素的使用与较低的空腹血糖（0.2 mmol/L低），但较高的2小时血糖水平（0.4 mmol/L高）相比，从未使用者。根据美国糖尿病协会或世界卫生组织对糖尿病的定义，或仅根据2小时血糖水平大于或等于11.1 mmol/l，与既往和从未使用者相比，它与2型糖尿病的风险无显著相关性。然而，2型糖尿病的风险增加，增加持续时间的雌激素使用之间的当前用户，每年的使用优势比为1.10（95%CI：1.01-1.19）。结论-数据表明，雌激素的使用在美国印第安绝经后妇女可能与葡萄糖耐量的恶化。目前使用雌激素的人使用雌激素的时间较长可能与2型糖尿病的风险增加有关。
OBJECTIVE - To examine the associations between estrogen use and levels of insulin and glucose as well as the effects of estrogen use on the risk of type 2 diabetes.RESEARCH DESIGN AND METHODS - this report is based on 857 women who were both nondiabetic and postmenopausal at the baseline examination (1989-1992) and who completed a second examination (1993-1995) an average of 4 years later. The participants were divided into three groups; never, past, and current users based on their baseline estrogen use status. ANCOVA was used to compare the insulin and glucose levels among estrogen use groups. Logistic regression was used to evaluate the association between estrogen use and the incidence of type 2 diabetes.RESULTS - Postmenopausal estrogen use was associated with lower fasting glucose (0.2 mmol/l lower) but higher 2-h glucose levels (0.4 mmol/l higher) compared with never users. It was not significantly associated with the risk of type 2 diabetes compared with past and never users, based on American Diabetes Association or World Health Organization definitions of diabetes or on only a 2-h glucose level greater than or equal to11.1 mmol/l. However, the risk of type 2 diabetes increased with increasing duration of estrogen use among current users, with an odds ratio of 1.10 per year of use (95% CI: 1.01-1.19).CONCLUSIONS - The data suggest that estrogen use in American Indian postmenopausal women may relate to deterioration of glucose tolerance. Longer duration of estrogen use among current users may relate to an increased risk of type 2 diabetes.