The identification of a complex A/G/I/J recombinant HIV type 1 virus in various West African countries.
The identification of a complex A/G/I/J recombinant HIV type 1 virus in various West African countries.
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在西非多个国家鉴定出复杂的 A/G/I/J 重组 HIV 1 型病毒。
DOI：
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发表时间：
1999
影响因子：
1.5
通讯作者：
Martine Peeters
中科院分区：
文献类型：
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作者：
C. Montavon;F. Bibollet;David Robertson;B. Koumare;C. Mulanga;E. Esu;Coumba Toure;Souleymane Mboup;Eric Saman;Eric Delaporte;Martine Peeters
在这个序列说明中，我们描述了一个HIV-1分离株的全长基因组序列，该分离株来自西非国家马里。从近全长基因组的系统发育树分析表明，95 ML 84菌株形成一个单独的集群，支持100%的自举值，与先前描述的A/G/J/？来自布基纳法索的花叶病毒BFP 90。另外的分析显示，在整个基因组中，在95 ML 84和BFP 90病毒之间观察到最低的多样性，并且bootscan分析显示了类似的复杂基因组结构。除了最初的报告将BFP 90病毒描述为A/G/J/？重组后，我们的数据表明，对于BFP 90和95 ML 84菌株，未分类区域对应于亚型I。A/G/I/J BFP 90和95 ML 84株代表了迄今为止检测到的第五种也是最复杂的HIV-1循环重组形式，我们的数据显示其存在于西非各国。亚型I和J序列，最初被认为是罕见的，似乎通过这些重组形式扩大了它们的地理分布。
In this sequence note we describe the full-length genome sequence of an HIV-1 isolate originating from the west African country of Mali. The phylogenetic tree analysis from the near full-length genome shows that the 95ML84 strain forms a separate cluster, supported by 100% of the bootstrap values, with the previously described A/G/J/? mosaic virus BFP90 from Burkina Faso. Additional analysis showed that throughout the genome the lowest diversity was seen between the 95ML84 and the BFP90 viruses, and bootscan analysis showed a similar complex genomic structure. In addition to the initial report describing the BFP90 virus as an A/G/J/? recombinant, our data show that for the BFP90 and 95ML84 strains the unclassified region corresponds to subtype I. The A/G/I/J BFP90 and 95ML84 strains represent the fifth and most complex circulating recombinant form of HIV-1 detected so far, and our data show its presence in various West African countries. Subtype I and J sequences, initially considered rare, seem to have broadened their geographical spread by way of these recombinant forms.