Natural Killer Cells as Novel Helpers in Anti-Herpes Simplex Virus Immune Response
Natural Killer Cells as Novel Helpers in Anti-Herpes Simplex Virus Immune Response
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DOI：
10.1128/jvi.00365-08
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发表时间：
2008-11-01
影响因子：
5.4
通讯作者：
Kumaraguru, Uday
中科院分区：
文献类型：
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作者：
Nandakumar, Subhadra;Woolard, Stacie N.;Kumaraguru, Uday
先天防御有助于消除感染，但其中一些也在塑造适应性免疫反应的强度和功效方面发挥着重要作用。在影响随后的适应性免疫方面，树突状细胞辅助的 NK 细胞可能是对单纯疱疹病毒 (HSV) 感染的先天反应最相关的组成部分。我们证实，缺乏或耗尽 NK 细胞的小鼠容易受到 HSV 诱导的病变的影响。在缺乏 NK 细胞的情况下产生的 CD+ 细胞毒性 T 淋巴细胞的数量和质量都会减少，从而导致对 HSV 诱导的脑炎的易感性。我们证明了 NK 细胞的新辅助作用，即 NK 细胞补偿 CD4 辅助 T 细胞的损失，并且 NK 细胞补充可增强野生型抗 HSV CD8 T 细胞的功能。此外，NK细胞能够部分拯救在缺乏CD4 T辅助细胞的情况下产生的功能失调的CD8(+) T细胞，从而发挥新的拯救功能。因此，在 CD4 辅助反应受到影响的情况下，NK 细胞很可能被用来增强和挽救 T 细胞反应。
Innate defenses help to eliminate infection, but some of them also play a major role in shaping the magnitude and efficacy of the adaptive immune response. With regard to influencing subsequent adaptive immunity, NK cells aided by dendritic cells may be the most relevant components of the innate reaction to herpes simplex virus (HSV) infection. We confirm that mice lacking or depleted of NK cells are susceptible to HSV-induced lesions. The quantity and quality of CD+ cytotoxic T lymphocytes generated in the absence of NK cells were diminished, thereby contributing to susceptibility to HSV-induced encephalitis. We demonstrate a novel helper role for NK cells, in that NK cells compensate for the loss of CD4 helper T cells and NK cell supplementation enhances the function of wild type anti-HSV CD8 T cells. In addition, NK cells were able to partially rescue the dysfunctional CD8(+) T cells generated in the absence of CD4 T helper cells, thereby performing a novel rescue function. Hence, NK cells may well be exploited for enhancing and rescuing the T-cell response in situations where the CD4 helper response is affected.