Mitochondrial DNA heterogeneity in Tunisian Berbers
Mitochondrial DNA heterogeneity in Tunisian Berbers
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DOI：
10.1046/j.1529-8817.2004.00096.x
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发表时间：
2004-05-01
影响因子：
1.9
通讯作者：
El gaaied, AB
中科院分区：
文献类型：
--
作者：
Fadhlaoui-Zid, K;Plaza, S;El gaaied, AB
柏柏尔人居住在北非各地，他们的起源和与邻居的遗传关系并不明确。对来自三个突尼斯柏柏尔人群体的155名个体的线粒体DNA（mtDNA）控制区的第一个高变片段进行了测序，并与其他北非人进行了比较。发现的线粒体DNA谱系属于北非已经描述的一组常见的线粒体DNA单倍群。除了原生的北非U6单倍群，一组L3谱系的特点是在位置16041的过渡似乎仅限于北非人，这表明这组谱系的扩张发生在大约10500年前的北非，并蔓延到邻近的人群。主成分和坐标分析表明，一些柏柏尔人群体（图阿雷格人，Mozabite，和Chenini-Douiret）的异常值在北非的遗传景观。该离群值位置与单倍型频率遗传漂变后的隔离过程一致，并且与AMOVA中显示的柏柏尔人与阿拉伯样品相比显示的高异质性一致。尽管柏柏尔人具有异质性，但柏柏尔人和阿拉伯人之间没有显著差异，这表明阿拉伯化主要是一个文化过程，而不是人口更替。
Berbers live in groups scattered across North Africa whose origins and genetic relationships with their neighbours are not well established. The first hypervariable segment of the mitochondrial DNA (mtDNA) control region was sequenced in a total of 155 individuals from three Tunisian Berber groups and compared to other North Africans. The mtDNA lineages found belong to a common set of mtDNA haplogroups already described in North Africa. Besides the autochthonous North African U6 haplogroup, a group of L3 lineages characterized by the transition at position 16041 seems to be restricted to North Africans, suggesting that an expansion of this group of lineages took place around 10500 years ago in North Africa, and spread to neighbouring populations. Principal components and the coordinate analyses show that some Berber groups (the Tuareg, the Mozabite, and the Chenini-Douiret) are outliers within the North African genetic landscape. This outlier position is consistent with an isolation process followed by genetic drift in haplotype frequencies, and with the high heterogeneity displayed by Berbers compared to Arab samples as shown in the AMOVA. Despite this Berber heterogeneity, no significant differences were found between Berber and Arab samples, suggesting that the Arabization was mainly a cultural process rather than a demographic replacement.