Prevalence and longitudinal stability of negative symptoms in healthy participants
Prevalence and longitudinal stability of negative symptoms in healthy participants
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DOI：
10.1002/gps.2284
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发表时间：
2009-12-01
影响因子：
4
通讯作者：
Jeste, Dilip V.
中科院分区：
文献类型：
--
作者：
Emmerson, Lindsay C.;Ben-Zeev, Dror;Jeste, Dilip V.
目的虽然老年精神分裂症患者的阴性症状突出，但尚不清楚这种模式是否在健康参与者中普遍存在。本研究的目的是评估是否存在阴性症状的健康人群，并确定它们是否与疾病相关的过程或正常的aging.Methods进行了系统的审查26项研究，管理阴性症状评估健康参与者进行。此外，213名（年龄> 40岁）健康参与者在基线和1年随访时完成了PANSS和SANS评分。100名参与者也完成了评级后3 years.Results在所有审查的研究中，阴性症状在大多数参与者缺席。在目前的研究中发现的大型纵向评估与中年到老年adulth.Conclusions两者合计，数据表明，健康的志愿者不患有突出的阴性症状。这一发现与以下假设一致：老年患者阴性症状的发生率和严重程度与正常衰老无关，而是与疾病相关过程有关。版权所有（C）2009约翰威利父子有限公司
Objective Although negative symptoms are prominent in older patients with schizophrenia, it is unknown whether this pattern is prevalent in healthy participants. The objective of this study was to evaluate whether negative symptoms are present in healthy populations and to determine whether they are linked to illness-related processes or normal aging.Methods A systemic review of 26 studies that have administered negative symptom assessments to healthy participants was conducted. In addition, 213 (age > 40 years old) healthy participants completed PANSS and SANS ratings at both baseline and 1-year follow-up. One-hundred participants also completed ratings after 3 years.Results Across all reviewed studies, negative symptoms were absent in the majority of participants. Comparable results were found in the current study's large longitudinal evaluation with middle-aged to older adults.Conclusions Taken together, the data suggest that healthy volunteers do not suffer from prominent negative symptoms. This finding is consistent with the hypothesis that the greater prevalence and severity of negative symptoms in older patients is not related to normal aging but to illness-related processes. Copyright (C) 2009 John Wiley & Sons, Ltd.