Oral myofibromas: report of two cases and review of clinical and histopathologic differential diagnosis
Oral myofibromas: report of two cases and review of clinical and histopathologic differential diagnosis
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DOI：
10.1016/j.tripleo.2008.02.022
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发表时间：
2008-06-01
期刊：
影响因子：
--
通讯作者：
Lopes, Marcio Ajudarte
中科院分区：
文献类型：
--
作者：
Azevedo, Rebeca De Souza;Pires, Fabio Ramoa;Lopes, Marcio Ajudarte
Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951. It may show clinical and histologic features that may be misinterpreted as a malignancy. We describe 2 cases of oral myofibromas affecting infants; the first one showed a rapid growth with teeth displacement and ulceration; the second one presented a relatively slow growth with an indolent course. Differential diagnosis included benign and malignant mesenchymal neoplasms, salivary gland tumors, and reactive processes. Microscopic analysis of both lesions revealed a spindle cell tumor with immunoreactivity for vimentin, muscle-specific actin, and specific smooth muscle isoform alpha-actin, rendering the diagnoses of myofibroma. The patients were treated with surgical excision, and both are in follow-up without any signs of recurrence. Myofibroma presents a wide range of differential diagnosis, including benign and malignant neoplasms. Therefore, accurate diagnosis may avoid an unnecessary aggressive therapy.
