Beyond cortical localization in clinico-anatomical correlation
Beyond cortical localization in clinico-anatomical correlation
复制标题
DOI：
10.1016/j.cortex.2012.07.001
复制
发表时间：
2012-11-01
期刊：
影响因子：
3.6
通讯作者：
Thiebaut de Schotten, Michel
中科院分区：
文献类型：
--
作者：
Catani, Marco;Dell'Acqua, Flavio;Thiebaut de Schotten, Michel
去年是保罗·布罗卡（Paul Broca）关于语言障碍的里程碑式病例报告发表150周年，该报告为随后的高级认知功能皮质定位研究铺平了道路。然而，许多复杂的功能依赖于分布式网络的活动，而不是单个皮层区域。因此，重要的是要了解大脑区域是如何在大规模网络中连接的，并将病变映射到连接的白色物质束上。为了促进这种网络方法，我们提供了一个与额叶，顶叶，枕叶，颞叶和边缘系统病变相关的经典神经系统综合征的概要。纤维束描记术研究的各种神经精神疾病的审查也包括在内。该概要附有一个新的地图集的基础上扩散张量纤维束成像的人类白色物质连接免费下载的http://www.natbrainlab.com。临床医生可以使用地图来准确地识别受传统CT或MRI可见病变影响的管道。该地图集还将帮助研究人员解释他们的群体分析结果。我们希望，大纲和地图集，通过允许一个精确的定位白色物质病变和相关症状，将有利于未来的工作，人类神经网络的功能相关性，从临床人群的研究。我们的目标是刺激临床医生制定一个关键的方法，临床解剖相关的研究，并扩大他们的临床解剖超出皮质表面，以涵盖功能障碍相关的连接途径。(C)2012 Elsevier Srl. All rights reserved.
Last year was the 150th anniversary of Paul Broca's landmark case report on speech disorder that paved the way for subsequent studies of cortical localization of higher cognitive functions. However, many complex functions rely on the activity of distributed networks rather than single cortical areas. Hence, it is important to understand how brain regions are linked within large-scale networks and to map lesions onto connecting white matter tracts. To facilitate this network approach we provide a synopsis of classical neurological syndromes associated with frontal, parietal, occipital, temporal and limbic lesions. A review of tractography studies in a variety of neuropsychiatric disorders is also included. The synopsis is accompanied by a new atlas of the human white matter connections based on diffusion tensor tractography freely downloadable on http://www.natbrainlab.com. Clinicians can use the maps to accurately identify the tract affected by lesions visible on conventional CT or MRI. The atlas will also assist researchers to interpret their group analysis results. We hope that the synopsis and the atlas by allowing a precise localization of white matter lesions and associated symptoms will facilitate future work on the functional correlates of human neural networks as derived from the study of clinical populations. Our goal is to stimulate clinicians to develop a critical approach to clinico-anatomical correlative studies and broaden their view of clinical anatomy beyond the cortical surface in order to encompass the dysfunction related to connecting pathways. (C) 2012 Elsevier Srl. All rights reserved.