Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome.
Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome.
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DOI：
10.1155/2015/785705
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发表时间：
2015
影响因子：
4.6
通讯作者：
Brzosko M
中科院分区：
文献类型：
--
作者：
Przepiera-Będzak H;Fischer K;Brzosko M
目标.探讨强直性脊柱炎（AS）、银屑病关节炎（PsA）和SAPHO综合征患者血清白细胞介素-6（IL-6）和白细胞介素-23（IL-23）水平及其与血管生成细胞因子和疾病活动性的相关性。患者和方法。我们研究了152例脊柱关节炎（SpA）患者：69例PsA，61例AS，22例SAPHO和29例对照。我们记录了年龄、性别、病程和治疗。我们评估了BASDAI、VAS和PASI评分。使用ELISA测定血清IL-6、IL-23、VEGF、EGF、FGFb和FGFa水平。我们估计了ESR和CRP。结果SpA患者血清IL-6、IL-23水平明显高于对照组（P < 0.00001和P = 0.0004）。AS（P = 0.000001）、PsA（P = 0.000001）和SAPHO（P = 0.0003）患者血清IL-6与CRP呈正相关。AS（P = 0.000001）、PsA（P = 0.002）和SAPHO（P = 0.02）患者血清IL-6与ESR呈正相关。SpA患者血清IL-6和IL-23水平与VAS、BASDAI和血管生成因子无相关性。结论. SpA患者血清IL-6与ESR、CRP相关，而IL-23与ESR、CRP无关。血清IL-6和IL-23与VAS、BASDAI和血管生成细胞因子无相关性。
Objectives. To assess serum interleukin-6 (IL-6) and interleukin-23 (IL-23) and their correlation with angiogenic cytokines and disease activity in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and SAPHO syndrome. Patients and Methods. We studied 152 spondyloarthritis (SpA) patients: 69 PsA, 61 AS, 22 SAPHO, and 29 controls. We recorded age, sex, disease duration, and treatment. We assessed BASDAI, VAS, and PASI scores. Serum IL-6, IL-23, VEGF, EGF, FGFb, and FGFa levels were determined using ELISA. We estimated ESR and CRP. Results. Serum IL-6 and IL-23 levels were higher in SpA than in control (P < 0.00001 and P = 0.0004, resp.). There was a positive correlation between serum IL-6 and CRP in AS (P = 0.000001), PsA (P = 0.000001), and SAPHO (P = 0.0003) patients. There was a positive correlation between serum IL-6 and ESR in AS (P = 0.000001), PsA (P = 0.002), and SAPHO (P = 0.02) patients. There was no correlation of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines in SpA. Conclusions. Serum IL-6 but not serum IL-23 correlated with ESR and CRP in SpA. No correlation was found of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines.