IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury
IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury
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DOI：
10.1212/01.wnl.0000178890.93795.0e
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发表时间：
2005-10-11
期刊：
影响因子：
9.9
通讯作者：
Karantanas, A
中科院分区：
文献类型：
--
作者：
Hadjigeorgiou, GM;Paterakis, K;Karantanas, A
目的：探讨（可变数串联重复）白介素（IL） 1RN和（-511）IL- 1b基因多态性与创伤性脑损伤（TBI）后脑出血事件的关系。方法：收集151例前瞻性TBI患者的脑CT、入院时格拉斯哥昏迷量表（GCS）、6个月格拉斯哥结局量表（GOS）和改良Rankin量表（mRS）的数据。采用标准方法测定IL-1RN和IL-1B基因型。有无任何类型的脑出血是主要结果。脑出血类型、入院时GCS、6个月GOS和mRS为次要结局。使用逻辑回归分析计算奇比（or）和相应的95% CI。在调整后的模型中，控制了年龄、性别、弥漫性脑水肿、颅内血肿体积、神经外科干预和入院时GCS的相关性。P值小于0.01被认为是显著的。结果：与非携带者相比，IL-1RN等位基因2携带者在TBI后发生脑出血的几率更高（调整后OR = 4.57; 95% CI = 1.67 ~ 12.96; p = 0.004）。（-511） IL-1B多态性的相关性不显著。结论：白细胞介素- 1rn等位基因2的存在与创伤后脑出血有关。
Objective: To investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI). Methods: Data from brain CT, Glasgow Coma Scale (GCS) at admission, and 6-month Glasgow Outcome Scale (GOS) and modified Rankin Scale (mRS) were collected for 151 prospectively recruited patients with TBI. IL-1RN and IL-1B genotypes were determined using standard methods. Presence vs absence of any type of brain hemorrhage was the main outcome. Type of brain hemorrhage, GCS at admission, and 6-month GOS and mRS were secondary outcomes. Odd ratios (ORs) and corresponding 95% CI were calculated using logistic regression analyses. In adjusted models, the associations were controlled for age, gender, diffuse brain edema, volume of intracranial hematoma, neurosurgical intervention, and GCS at admission. p values less than 0.01 were considered significant. Results: Compared with noncarriers, IL-1RN allele 2 carriers had higher odds of having cerebral hemorrhages after TBI ( adjusted OR = 4.57; 95% CI = 1.67 to 12.96; p = 0.004). The associations for (-511) IL-1B polymorphism were not significant. Conclusion: There is an association between the presence of interleukin-1RN allele 2 and posttraumatic brain hemorrhage.