White Matter Microstructure is Associated with Auditory and Tactile Processing in Children with and without Sensory Processing Disorder.
White Matter Microstructure is Associated with Auditory and Tactile Processing in Children with and without Sensory Processing Disorder.
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白质微观结构与患有和没有感觉处理障碍的儿童的听觉和触觉处理有关。
DOI：
10.3389/fnana.2015.00169
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发表时间：
2015
影响因子：
2.9
通讯作者：
Mukherjee P
中科院分区：
文献类型：
--
作者：
Chang YS;Gratiot M;Owen JP;Brandes-Aitken A;Desai SS;Hill SS;Arnett AB;Harris J;Marco EJ;Mukherjee P
感觉加工障碍(SPD)影响多达16%的学龄儿童，并导致影响受影响的个人及其家庭的认知和行为缺陷。虽然自闭症儿童的感觉加工差异现在得到了广泛的认识，但基于感觉功能障碍的儿童如果不符合基于社交沟通缺陷的自闭症标准，实际上仍然没有得到研究。在先前的先导性扩散张量成像(DTI)研究中，我们证明SPD的男孩已经改变了主要影响大脑后束的白质微结构，这削弱了感觉处理和整合。这破坏了微结构的完整性，测量为减少的白质分数各向异性(FA)，与父母报告的非典型感觉行为测量相关。在这项研究中，我们深入研究了白质微结构与触觉和听觉功能的关系，对8-12岁的儿童进行了更大的混合性别队列。我们继续发现与典型发育儿童(TDC)相比，SPD儿童的后脑白质微结构发生了明显的变化，同时还有更多的空间分布的变化。我们发现FA与父母报告以及儿童触觉和听觉处理的直接测量都有很强的相关性，与相应的父母报告测量相比，触觉和听觉处理的直接评估测量显示出更强和更连续的映射到潜在的白质完整性。基于这些微结构作为神经感觉加工能力相关性的发现，弥散磁共振成像值得进一步研究，作为寻找儿童SPD诊断、预后和治疗反应的生物标志物的工具。据我们所知，这项工作首次证明了直接测量的触觉和非语言听觉功能与脑白质微结构完整性的关联--不仅在SPD儿童中，在TDC中也是如此。
Sensory processing disorders (SPDs) affect up to 16% of school-aged children, and contribute to cognitive and behavioral deficits impacting affected individuals and their families. While sensory processing differences are now widely recognized in children with autism, children with sensory-based dysfunction who do not meet autism criteria based on social communication deficits remain virtually unstudied. In a previous pilot diffusion tensor imaging (DTI) study, we demonstrated that boys with SPD have altered white matter microstructure primarily affecting the posterior cerebral tracts, which subserve sensory processing and integration. This disrupted microstructural integrity, measured as reduced white matter fractional anisotropy (FA), correlated with parent report measures of atypical sensory behavior. In this present study, we investigate white matter microstructure as it relates to tactile and auditory function in depth with a larger, mixed-gender cohort of children 8–12 years of age. We continue to find robust alterations of posterior white matter microstructure in children with SPD relative to typically developing children (TDC), along with more spatially distributed alterations. We find strong correlations of FA with both parent report and direct measures of tactile and auditory processing across children, with the direct assessment measures of tactile and auditory processing showing a stronger and more continuous mapping to the underlying white matter integrity than the corresponding parent report measures. Based on these findings of microstructure as a neural correlate of sensory processing ability, diffusion MRI merits further investigation as a tool to find biomarkers for diagnosis, prognosis and treatment response in children with SPD. To our knowledge, this work is the first to demonstrate associations of directly measured tactile and non-linguistic auditory function with white matter microstructural integrity – not just in children with SPD, but also in TDC.