Application of chemical reaction engineering principles to 'body-on-a-chip' systems.
Application of chemical reaction engineering principles to 'body-on-a-chip' systems.
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DOI：
10.1002/aic.16448
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发表时间：
2018-11
期刊：
影响因子：
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通讯作者：
J. Sung;Ying I. Wang;J. H. Kim;J. M. Lee;M. Shuler
中科院分区：
文献类型：
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作者：
J. Sung;Ying I. Wang;J. H. Kim;J. M. Lee;M. Shuler
细胞培养模型与微尺度技术的结合促进了体外细胞微生理模型的出现，也被称为器官芯片系统。人体芯片系统是一种模拟生理关系的芯片上的多器官系统，可以再现器官-器官相互作用和潜在的全身对药物的反应，也可以作为疾病模型。化学反应工程原理可以应用于理解细胞或人体内部的复杂反应，这可以被视为一个多反应器系统。这些系统使用基于生理的药代动力学（PBPK）模型来指导身体微尺度系统的发展，其中器官或组织由活细胞或组织代表，并集成到人体芯片系统中。在这里，我们简要概述了化学反应工程的概念，以及如何将其原理应用于理解和预测人体芯片系统的行为。
The combination of cell culture models with microscale technology has fostered emergence of in vitro cell-based microphysiological models, also known as organ-on-a-chip systems. Body-on-a-chip systems, which are multi-organ systems on a chip to mimic physiological relations, enable recapitulation of organ-organ interactions and potentially whole-body response to drugs, as well as serve as models of diseases. Chemical reaction engineering principles can be applied to understanding complex reactions inside the cell or human body, which can be treated as a multi-reactor system. These systems use physiologically-based pharmacokinetic (PBPK) models to guide the development of microscale systems of the body where organs or tissues are represented by living cells or tissues, and integrated into body-on-a-chip systems. Here, we provide a brief overview on the concept of chemical reaction engineering and how its principles can be applied to understanding and predicting the behavior of body-on-a-chip systems.