Core-shell gold-nickel nanostructures as highly selective and stable nonenzymatic glucose sensor for fermentation process
Core-shell gold-nickel nanostructures as highly selective and stable nonenzymatic glucose sensor for fermentation process
复制标题
核壳金镍纳米结构作为发酵过程中高选择性和稳定的非酶葡萄糖传感器
DOI：
10.1038/s41598-020-58403-x
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发表时间：
2020-01-28
影响因子：
4.6
通讯作者：
Yang, Jun
中科院分区：
文献类型：
--
作者：
Gao, Xuejin;Du, Xinzhao;Yang, Jun
基于贵金属的非酶电极在葡萄糖检测中具有良好的选择性和高灵敏度，但没有容易受pH、温度和有毒化学物质影响等缺点。本文通过油胺还原金属前驱体制备了具有核壳结构的球形金-镍纳米颗粒（Au@Ni）。在适当的Au/Ni比下，核壳Au@Ni纳米颗粒结合了Au的高电催化活性、良好的选择性和生物相容性，以及Ni对氯离子（Cl−）和葡萄糖催化氧化中毒中间体的显著耐受性，作为葡萄糖检测的传感器。与SCE相比，该电极对葡萄糖氧化具有0.10 V的低工作电压，与其他基于Au和ni的传感器相比，具有更高的选择性。葡萄糖检测的线性范围为0.5 ~ 10 mmol L−1，快速响应时间约为3 s，稳定性好，灵敏度为23.17 μA cm−2mM−1，检出限为0.0157 mM。该传感器具有较高的抗毒性，不易被Cl−in溶液吸附中毒。
Non-enzymatic electrodes based on noble metals have excellent selectivity and high sensitivity in glucose detection but no such shortcomings as easy to be affected by pH, temperature, and toxic chemicals. Herein, spherical gold-nickel nanoparticles with a core-shell construction (Au@Ni) are prepared by oleylamine reduction of their metal precursors. At an appropriate Au/Ni ratio, the core-shell Au@Ni nanoparticles as a sensor for glucose detection combine the high electrocatalytic activity, good selectivity and biological compatibility of Au with the remarkable tolerance of Ni for chlorine ions (Cl−) and poisoning intermediates in catalytic oxidation of glucose. This electrode exhibits a low operating voltage of 0.10 V vs. SCE for glucose oxidation, leading to higher selectivity compared with other Au- and Ni-based sensors. The linear range for the glucose detection is from 0.5 mmol L−1to 10 mmol L−1with a rapid response time of ca. 3 s, good stability, sensitivity estimated to be 23.17 μA cm−2mM−1, and a detection limit of 0.0157 mM. The sensor displays high anti-toxicity, and is not easily poisoned by the adsorption of Cl−in solution.