Synthesis and characterization of salicylic acid-based poly(anhydride-ester) copolymers
Synthesis and characterization of salicylic acid-based poly(anhydride-ester) copolymers
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DOI：
10.1177/0883911506062976
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发表时间：
2006-03-01
影响因子：
1.7
通讯作者：
Uhrich, KE
中科院分区：
文献类型：
--
作者：
Schmeltzer, RC;Uhrich, KE
采用熔融缩聚法合成了聚1，10-二(邻羧基苯氧基)正己酸(CPD)和聚(1，6-二(对羧基苯氧基)己烷)(p-CPH)共聚物。含有CPD的聚(酸酐-酯)可被降解成水杨酸，然而，这些均聚物具有机械和热特性，限制了它们在临床上的应用。研究了CPD与p-CPH的共聚物的合成和表征，p-CPH是一种机械稳定的均聚物。通过改变CPD与p-CPH单体的比例，共聚物的水杨酸负载量和热/力学性能是控制因素；增加CPD浓度会增加水杨酸盐的负载量，但会降低聚合物的稳定性；而增加p-CPH浓度则会增加共聚物的热稳定性和机械稳定性。具体地说，降低CPD：P-CPH的比例会降低水杨酸盐的负载量，提高热分解温度。玻璃化转变温度(摄氏度)从27摄氏度到38摄氏度不等，这是弹性生物医学植入物的理想范围。
A series of poly(anhydride-esters) based on poly(1,10-bis(o-carboxyphenoxy)decanoate) (CPD) and poly(1,6-bis(p-carboxyphenoxy)hexane) (p-CPH) were synthesized by melt-condensation polymerization. Poly(anhydride-esters) that contain CPD hydrolytically degraded into salicylic acid, however, these homopolymers have mechanical and thermal characteristics that limit their use in clinical applications. The synthesis and characterization of copolymers of CPD with p-CPH, a monomer known to generate mechanically stable homopolymers, was investigated. By changing the CPD to p-CPH monomer ratios, the salicylic acid loading and thermal/mechanical properties of the copolymers was a controlling factor; increasing the CPD concentration increased the salicylate loading but decreased the polymer stability; whereas increasing the p-CPH concentration increased the thermal and mechanical stability of the copolymers. Specifically, decreasing the CPD:p-CPH ratio resulted in lower salicylate loading and increased thermal decomposition temperatures. The glass transition temperatures (degrees C) varied from 27 to 38 degrees C, a desirable range for elastomeric biomedical implants.