Viruses and acute otitis media
Viruses and acute otitis media
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DOI：
10.1097/00006454-200010000-00013
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发表时间：
2000-10-01
影响因子：
3.6
通讯作者：
Heikkinen, T
中科院分区：
文献类型：
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作者：
Chonmaitree, T;Heikkinen, T
通过鼻咽中11/27/2023细胞上的BhDMf 5ePHKbH 4 TTImqenVA + lpWIIBvonhQl 60 EtgtdlLYrLzSPu + hQedJnbNaXBf下载。这些物质中的许多已被证明会引起成年志愿者的ET功能障碍。病毒还增强鼻咽细菌定植和粘附，并改变宿主的免疫防御。例如，流感病毒促进了肺炎链球菌在成年志愿者口咽部的定植，RSV增加了流感嗜血杆菌在棉鼠鼻咽部的定植。RSV、腺病毒和甲型流感病毒增加了S.肺炎链球菌和H.流感病毒对体外上皮细胞的作用。病毒还调节宿主的免疫功能，并增加宿主对继发性细菌感染的易感性。例如，流感病毒对多形核白细胞具有免疫抑制作用，10而RSV和鼻病毒可改变细胞介导的免疫功能。十一，十二
Downloaded from by BhDMf5ePHKbH4TTImqenVA+ lpWIIBvonhQl60EtgtdlLYrLzSPu+ hQedJnbNaXBf on 11/27/2023 cells in the nasopharynx. 3 Many of these substances have been shown to provoke ET dysfunction in adult volunteers. Viruses also enhance nasopharyngeal bacterial colonization and adherence and alter the host’s immune defense. For example, influenza virus promoted colonization by Streptococcus pneumoniae in the oropharynx of adult volunteers and RSV increased nasopharyngeal colonization by Haemophilus influenzae in cotton rats. RSV, adenovirus and influenza A increased adherence of S. pneumoniae and H. influenzae to epithelial cells in vitro. Viruses also modulate the host’s immune function and increase the host susceptibility to secondary bacterial infection. For example, influenza virus has immunosuppressive effects on polymorphonuclear leukocytes, 10 and RSV and rhinovirus can alter cell-mediated immune function. 11, 12