Age-related decline in dopamine transporters - Analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries
Age-related decline in dopamine transporters - Analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries
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DOI：
10.1176/appi.ajgp.10.1.36
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发表时间：
2002-01-01
影响因子：
7.2
通讯作者：
Innis, RB
中科院分区：
文献类型：
--
作者：
van Dyck, CH;Seibyl, JP;Innis, RB
神经成像研究证明纹状体多巴胺转运体(DAT)作为多巴胺能神经变性的标志物与年龄相关的下降。作者进一步阐明了这种神经系统在健康衰老中的作用，这与帕金森病(PD)不同。用[I-123]2beta-carbomethoxy-3beta-(4-iodo-phenyl)tropane([I-123]β-CIT)和单光子发射计算机断层扫描(SPECT)研究了年龄对纹状体DAT可用性的影响。纹状体DAT的可用性(V-3“)与年龄呈显著负相关，在18-88岁之间以近乎线性的方式下降46%，或每十年下降6.6%。尾状核(48%)和壳核(45%)的下降速度与年龄相当，左右不对称的程度随着年龄的增加而微乎其微。大脑半球的不对称性与受试者的利手无关。7，这些结果表明，衰老与两个半球尾状核和壳核的DAT相对对称的丢失有关。这些发现不仅对健康衰老，而且对神经退行性疾病，如帕金森病，也有意义。
Neuroimaging studies have documented an age-related decline in striatal dopamine transporters (DATs) as a marker of dopaminergic neurodegeneration. The authors further elucidated the effects oil this neural system in healthy aging, ill contrast to Parkinson disease (PD). The effects of age on striatal DAT availability were examined in a large, healthy subject sample (N = 126) with [I-123]2beta-carbomethoxy-3beta-(4-iodo-phenyl)tropane ([I-123]beta-CIT) and single photon emission computed tomography (SPECT). Striatal DAT availability (V-3") showed a significant inverse correlation with age, declining in a nearly linear manner by 46% over the age range 18 to 88 years, or 6.6% per decade, Rates of decline were comparable for caudate (48%,) and putamen (45%), with only minimal increase in left-right asymmetry with age. Hemispheric asymmetries were unrelated to the handedness of subjects. 7,These results demonstrate that aging is associated with a relatively symmetric loss of DATs in the caudate and putamen in both hemispheres. These findings have implications not only for healthy aging but also for neurodegenerative disorders such as PD.