Nanotheranostic approaches for management of bloodstream bacterial infections
Nanotheranostic approaches for management of bloodstream bacterial infections
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DOI：
10.1016/j.nano.2016.09.005
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发表时间：
2017-01-01
影响因子：
5.4
通讯作者：
Gupta, Shalini
中科院分区：
文献类型：
--
作者：
Jagtap, Pramod;Sritharan, Venkataraman;Gupta, Shalini
血液细菌感染是对全球公共卫生和经济的严重威胁。美国国家卫生统计中心最近公布的数据显示，每年有100多万美国人受到感染，仅败血症死亡率就约为28%-50%，Hall等人。(2011)。1因此，迫切需要强大和负担得起的医疗保健点医疗技术，以便迅速作出决定，启动适当的治疗路线。目前基于血液培养和血清学的技术没有快速的周转时间或足够的敏感性来进行早期干预。此外，抗菌素耐药性对实现有效的细菌感染管理构成了巨大的挑战。Nantheranostics正在成为一种新的策略，它以一种更个性化的方式结合了快速诊断和治疗的解决方案。本文综述了近年来利用不同种类的纳米材料和生物受体治疗血流细菌感染的研究进展，并讨论了目前面临的挑战和未来的发展方向。(C)2016 Elsevier Inc.保留所有权利。
Bloodstream bacterial infections are a serious threat to global public health and economy. The recent figures released by National Center for Health Statistics indicate that more than a million Americans get affected by it each year and the sepsis mortality alone is about 28%-50% Hall et al. (2011). 1 Robust and affordable point-of-care medical technologies are, therefore, urgently needed for rapid decision-making to initiate appropriate line of treatment. Current techniques based on blood culture and serology do not have quick turnaround times or adequate sensitivities for early intervention. Moreover, antimicrobial resistance poses a great challenge in the fight towards effective bacterial infection management. Nanotheranostics is emerging as a novel strategy combining solutions for rapid diagnosis and treatment in a more personalized way. This review highlights the recent advances made in theranosis of bloodstream bacterial infections using different classes of nanomaterials and bioreceptors, and discusses present challenges and future way forward. (C) 2016 Elsevier Inc. All rights reserved.