Short Communication: Low False Recent Rate of Limiting Antigen-Avidity Assay Combined with HIV-1 RNA Data in Botswana.
Short Communication: Low False Recent Rate of Limiting Antigen-Avidity Assay Combined with HIV-1 RNA Data in Botswana.
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简短的交流：博茨瓦纳限制性抗原亲和力测定与 HIV-1 RNA 数据相结合的近期错误率较低。
DOI：
10.1089/aid.2016.0127
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发表时间：
2017
影响因子：
1.5
通讯作者：
Es
中科院分区：
文献类型：
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作者：
Moyo,Sikhulile;Kotokwe,KenanaoP;Mohammed,Terence;Boleo,Corretah;Mupfumi,Lucy;Chishala,Samuel;Tsalaile,Lesedi;Bussmann,Hermann;Gaseitsiwe,Simani;Musonda,Rosemary;Makhema,Joseph;Baum,Marianna;Marlink,Richard;Engelbrecht,Susan;Es
Cross-sectional estimation of HIV incidence could misclassify some established or chronic HIV infections as recent. Usually long-term nonprogressors, elite and viremic controllers, and individuals on ART contribute to misclassification. Local data on the false recent rate (FRR) could minimize misclassification during estimation of HIV incidence. To improve monitoring of HIV incidence, we estimated local FRR in Botswana. A total of 1,036 specimens from individuals infected for at least 1.5–2 years were sampled between 2004 and 2009 and tested using the limiting antigen (LAg)-avidity assay using a cutoff of 1.5 normalized optical density units. The FRR was 0.97% (10/1,036; 95% confidence interval [CI] 0.46–1.77). Four samples had HIV-1 RNA >1,000 cps/ml, giving an adjusted FRR of 0.39% (4/1,036; 95% CI 0.11–0.99). A combination of LAg and HIV-1 RNA load data resulted in FRR below 1% in the Botswana population.
