NINHYDRIN POSITIVE SUBSTANCES PRESENT IN DIFFERENT AREAS OF NORMAL RAT BRAIN *
NINHYDRIN POSITIVE SUBSTANCES PRESENT IN DIFFERENT AREAS OF NORMAL RAT BRAIN *
复制标题
茚三酮阳性物质存在于正常大鼠大脑的不同区域 *
作者：
R. K. Shaw;J. Heine
对大鼠全脑茚三酮阳性物质的早期研究（Roberts、Lowe、Guth和Jelinek，1958）表明，这些物质不会因各种药物处理或生理应激而改变。当时有人提到，对整个大脑的研究可能会产生误导。后来对大鼠和小鼠全脑的研究（Häkkinen和Kulonen，1961年; Soep和Janssen，1961年; DeRopp和Snedeker，1961年; Kamrin和Kamrin，1961年）表明，给予不同的药物确实会改变几种游离氨基酸的浓度。虽然没有明显的有意义的变化模式，但这些报告提出了一种可能性，即通过采用更精确的技术进行更详细的研究，可以发现有意义的变化模式。
Early investigations (Roberts, Lowe, Guth and Jelinek, 1958) of the ninhydrin positive substances of the whole brain of rats indicated that these substances were unchanged by various drug treatments or physiological stresses. It was mentioned at that time that studies of the whole brain could be misleading. Later work with whole brains of rats and mice (Häkkinen and Kulonen, 1961; Soep and Janssen, 1961; DeRopp and Snedeker, 1961; Kamrin and Kamrin, 1961) revealed that the administration of different drugs does alter the concentration of several of the free amino acids. Although no meaningful pattern of changes was evident, these reports raised the possibility that a meaningful pattern of changes could be found through a more detailed study with more refined techniques.