Comparative epidemiology of breast cancer among men and women in the US, 1996 to 2000
Comparative epidemiology of breast cancer among men and women in the US, 1996 to 2000
复制标题
DOI：
10.1007/s10552-005-5384-y
复制
发表时间：
2006-03-01
影响因子：
2.3
通讯作者：
Wilkens, LR
中科院分区：
文献类型：
--
作者：
Goodman, MT;Tung, KH;Wilkens, LR
由于这种恶性肿瘤相对罕见，很少对男性乳腺癌进行调查。本分析的目的是比较男性和女性乳腺癌的人口统计学、病理学和临床特征，在1996年至2000年期间，通过34个美国人口登记处确定了6379名男性和744,275名女性乳腺癌。这些登记研究估计代表了69%的美国人群。根据2000年美国人口普查数据计算每百万人口的乳腺癌校正发病率（AAIR），男性乳腺癌的AAIR（16.6）明显低于女性（1557.7）。黑人男性的乳腺癌发病率高于白色和亚太岛屿男性，而女性的乳腺癌发病率则高于其他族裔群体。与女性相似，非西班牙裔男性的乳腺癌发病率比西班牙裔男性高50%。导管癌是男女患者中最常见的组织学类型。小叶癌的发病率在男性中是罕见的，但佩吉特病和乳头状癌发生在女性中的相对频率低于男性。小叶乳腺癌在黑人男性和女性中比在其他种族群体中更不常见。10.8%的男性和16.2%的女性被诊断为原位乳腺癌。局部乳腺癌是男女和所有族裔群体中最常见的诊断阶段，尽管妇女比男子更有可能在局部阶段被诊断出来。在男性中，左侧乳房比右侧乳房诊断出癌症的可能性高10%，而女性为4%。尽管男性乳腺癌的发病率很低，但这种恶性肿瘤的描述性流行病学与女性惊人地相似。对黑人男性乳腺癌相对发病率较高的解释是一个研究挑战。
Few investigations of breast cancer among men have been conducted because of the relative rarity of this malignancy. The objective of this analysis was to compare the demographic, pathological, and clinical features of breast cancer among men and women.Breast cancer among 6379 men and 744,275 women was identified through 34 US population-based registries in the US during the period 1996 to 2000. These registries were estimated to represent 69% of the US population. Age-adjusted incidence rates (AAIR) were calculated per million population using counts derived from the 2000 US census.The AAIR of breast cancer among men (16.6) was substantially lower than the incidence among women (1557.7). Rates of breast cancer among black men were higher than among white and Asian-Pacific Island men, in contrast to women among whom rates in whites exceeded those among other ethnic groups. Similar to women, breast cancer rates among non-Hispanic men were 50% greater than among Hispanic men. Ductal cancer was the most common histologic type diagnosed in both sexes. The incidence of lobular cancer was rare in men, but Paget's disease and papillary carcinoma occurred with lower relative frequency in women than in men. Lobular breast cancers were less common among black men and women than among other ethnic groups. In situ breast cancer was diagnosed in 10.8% of men and 16.2% of women. Localized breast cancer was the most common stage at diagnosis in both sexes and all ethnic groups, although women were more likely than men to be diagnosed at a localized stage. Cancer was 10% more likely to be diagnosed in the left breast than the right breast among men compared to 4% in women.In spite of the rare incidence of breast cancer in men, the descriptive epidemiology of this malignancy is surprisingly similar to that in women. An explanation for the greater relative incidence of breast cancer in black men is a research challenge.